Grant winners

September 25, 2014

National Institute for Health Research

Health Technology Assessment Programme

Stratified care for patients with sciatica and suspended sciatica in primary care: a randomised trial (the SCOPiC trial - sciatica outcomes in primary care)

Comparison of Alitretinoin with PUVA as the first-line treatment in patients with severe chronic hand eczema

Health Services and Delivery Research Programme

  • Award winner: Alan Simpson
  • Institution: City University London
  • Value: £366,618

Cross-national comparative study of recovery-focused mental healthcare planning in acute inpatient mental health settings (COCAPP-A)

A multi-centre randomised controlled trial of comprehensive geriatric assessment in an admission-avoidance hospital-at-home setting

Public Health Research Programme

The filter further education challenge pilot trial and process evaluation of a multi-level smoking prevention intervention in further education settings

 

Leverhulme Trust

International Network Grants
Sciences

A Darwinian framework for phenotypically integrating genetic and epigenetic cues

Social sciences

Critical autism network: policy, practice and identities in five national contexts

Global science ‘scapes: dimensions of transnationalism

Grey-systems and its applications

In detail

John Connelly, Queen Mary University of London

Dr Hadwen Trust

Award winner: John Connelly
Institution: Queen Mary University of London
Value: £117,823

High-throughput analysis of synthetic wound-healing microenvironment

This project will use human cells instead of animal cells to investigate wound healing and to improve the testing of drugs and therapeutics. Chronic, non-healing wounds are costly and difficult-to-treat conditions and are thus a major healthcare concern in the UK. The study aims to develop an engineered in vitro model of wound healing where many different components of the wound environment can be controlled and analysed. The team then intends to use this model to identify combinations of different adhesive proteins and internal-signalling molecules that regulate wound closure. The results of these studies will provide new and important insights into the regulatory mechanisms that are involved in wound healing. In addition, the study will establish a novel experimental platform that could replace many animal studies and improve pre-clinical testing of drugs and therapeutics.

 

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