Grant winners

January 28, 2010

NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT AND REDUCTION OF ANIMALS IN RESEARCH

The NC3Rs has awarded its first PhD studentships to five early-career scientists within UK institutions as part of its aim to advance the knowledge and application of methods to replace, refine and reduce animal experiments.

Award winner: Hannah Buchanan-Smith

Institution: University of Stirling

Refinement of rearing practices in marmosets

Award winner: Jane Hurst

Institution: University of Liverpool

Taming anxiety and variation in laboratory mice

Award winner: Gareth Jenkins

Institution: Swansea University

The validation of defined genotoxic thresholds, leading to better in-vitro risk assessments of carcinogenic potential

Award winner: Donna MacCallum

Institution: University of Aberdeen

An in-vitro model system to assay kidney-pathogen interactions determining the outcome of Candida albicans infection

Award winner: Matthew Wright

Institution: Newcastle University

Applying the 3Rs to liver fibrosis research

Engineering and Physical Sciences Research Council

Award winner: N.I.M. Gould

Institution: Science and Technology Facilities Council Laboratories

Value: £12,104

Iterative methods for PDE-constrained optimisation

Award winner: J. Glass

Institution: Loughborough University

Value: £80,063

APRES: Action Programme on REsponsible Sourcing

Award winner: D.R. Leadley

Institution: University of Warwick

Value: £477,121

Room temperature terahertz quantum cascade lasers on silicon substrates

Award winner: G. Plotkin

Institution: University of Edinburgh

Value: £31,980

The 2010 Federated Logic Conference

Award winner: R.W. Kelsall

Institution: University of Leeds

Value: £6,578

Room temperature terahertz quantum cascade lasers on silicon substrates

Award winner: D.J. Paul

Institution: University of Glasgow

Value: £643,144

Room temperature terahertz quantum cascade lasers on silicon substrates

MUSCULAR DYSTROPHY CAMPAIGN

Award winner: George Dickson

Institution: Royal Holloway, University of London

Value: £130,931

Investigating methods to improve the efficiency of a gene-therapy approach in the treatment of Duchenne muscular dystrophy

Award winner: Kate Bushby

Institution: Newcastle University

Value: £123,809

Examining the underlying cause of the dysferlinopathies

Award winner: Kay Davies

Institution: University of Oxford

Value: £170,045

Improving the efficiency of the "molecular patch" gene-therapy approach

Award winner: David Beeson

Institution: University of Oxford

Value: £91,950

Investigating the underlying causes and potential treatments of myasthenia gravis and the congenital myasthenic syndromes

IN DETAIL

Award winner: John Weinman

Institution: King's College London

Value: £61,000

Improving the quality of life for individuals with neuromuscular conditions

This grant will help fund research into psychological coping techniques for people with presently incurable neuromuscular conditions. Professor Weinman, professor of psychology as applied to medicine at King's Institute of Psychiatry, studies the self-management of chronic illness. In this three-year project, he will seek to investigate varying psychological techniques that people with muscle-wasting diseases can use to positive effect.

More than 60,000 people in the UK suffer from muscular dystrophy or related conditions, which cause muscles in the body to weaken and can also affect heart and respiratory muscles. Professor Weinman said: "Together with Michael Rose at King's College Hospital, our work has investigated the ways that patients with muscle disease perceive their condition. These perceptions can influence their ability to cope with their disease and, in turn, adversely affect their quality of life. This grant will enable us to develop and test new treatments."

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