Gut feelings in common

January 13, 2011



Credit: Paola Cognigni/Irene Miguel-Aliaga


Scientists have devised a method of studying metabolism using the droppings of fruit flies. Researchers at the University of Cambridge, led by Irene Miguel-Aliaga, studied the droppings produced following various genetic manipulations of the nerve cells in flies' intestines. They discovered that many of the cells have specific functions, such as regulating appetite and water balance, and believe their research may provide important clues as to why pregnant women suffer from bloating and constipation and why there might be a link between a low-calorie diet and longevity. "Humans and fruit flies reproduce in very different ways, yet the associated symptoms of constipation and bloating and their cause - a reproductive hormone - are the same," Dr Miguel-Aliaga said. Images of fruit fly gut and nerve cells taken with a confocal microscope aided the researchers in their work.

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