The Ara Parseghian Medical Research Foundation announces an unrestricted request for applications directed toward understanding the cause and/or developing a treatment for Niemann Pick Type C (NPC) disease.
The Foundation will fund research proposals for up to a two-year period (renewable thereafter), at a maximum of $125,000 per year, excluding salary support for the P.I. Investigators new to this field are encouraged to apply for funding.
Targeted areas of emphasis include:
1. Cell Biology of the NPC1 and NPC2 proteins: Elucidation of the intracellular function(s) of the NPC1 and NPC2 proteins with particular emphasis on fully characterizing the role of these proteins in vesicular trafficking and intracellular signaling.
2. Neurobiology of NPC disease: Determination of the molecular pathogenesis of NPC disease in the CNS with particular emphasis on defining the function of the NPC-1 and NPC-2 proteins in the CNS.
3. Clinical Trials and NPC disease: Identification of surrogate endpoints in NPC patients by non-invasive imaging, neurophysiological testing and/or genomics/proteomics approaches. Design of novel assays to screen for bioactive compounds that may prove therapeutically efficacious in NPC disease.
Address: Ara Parseghian Medical Research Foundation
1760 East River Road
Telephone: (520) 577 5106
Fax: (520) 577 5212