The next big bang: biology and medicine papers

May 25, 2017
Mosquito

These are all the papers relating to the "biology and medicine" research fronts in the article What are the hot research areas that might spark the next big bang?, published in Times Higher Education on 25 May 2017. 

Research front: Structure, transmission, action, and potential inhibitors of Zika virus 

Paper 1

Title: Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

Author(s): Nowakowski, TJ (Nowakowski, Tomasz J.); Pollen, AA (Pollen, Alex A.); Di Lullo, E (Di Lullo, Elizabeth); Sandoval-Espinosa, C (Sandoval-Espinosa, Carmen); Bershteyn, M (Bershteyn, Marina); Kriegstein, AR (Kriegstein, Arnold R.)

Source: CELL STEM CELL  Volume: 18  Issue: 5  Pages: 591-596  DOI: 10.1016/j.stem.2016.03.012  Published: MAY 5 2016  

Times Cited in Web of Science Core Collection: 43

Total Times Cited: 44


Paper 2

Title: The 3.8 angstrom resolution cryo-EM structure of Zika virus

Author(s): Sirohi, D (Sirohi, Devika); Chen, ZG (Chen, Zhenguo); Sun, L (Sun, Lei); Klose, T (Klose, Thomas); Pierson, TC (Pierson, Theodore C.); Rossmann, MG (Rossmann, Michael G.); Kuhn, RJ (Kuhn, Richard J.)

Source: SCIENCE  Volume: 352  Issue: 6284  Pages: 467-470  DOI: 10.1126/science.aaf5316  Published: APR 22 2016  

Times Cited in Web of Science Core Collection: 42

Total Times Cited: 46


Paper 3

Title: Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

Author(s): Bayer, A (Bayer, Avraham); Lennemann, NJ (Lennemann, Nicholas J.); Ouyang, YS (Ouyang, Yingshi); Bramley, JC (Bramley, John C.); Morosky, S (Morosky, Stefanie); Marques, ETD (De Azeved Marques, Ernesto Torres, Jr.); Cherry, S (Cherry, Sara); Sadovsky, Y (Sadovsky, Yoel); Coyne, CB (Coyne, Carolyn B.)

Source: CELL HOST & MICROBE  Volume: 19  Issue: 5  Pages: 705-712  DOI: 10.1016/j.chom.2016.03.008  Published: MAY 11 2016  

Times Cited in Web of Science Core Collection: 39

Total Times Cited: 39


Paper 4

Title: Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

Author(s): Dang, J (Dang, Jason); Tiwari, SK (Tiwari, Shashi Kant); Lichinchi, G (Lichinchi, Gianluigi); Qin, Y (Qin, Yue); Patil, VS (Patil, Veena S.); Eroshkin, AM (Eroshkin, Alexey M.); Rana, TM (Rana, Tariq M.)

Source: CELL STEM CELL  Volume: 19  Issue: 2  Pages: 258-265  DOI: 10.1016/j.stem.2016.04.014  Published: AUG 4 2016  

Times Cited in Web of Science Core Collection: 34

Total Times Cited: 34


Paper 5

Title: Structure of the thermally stable Zika virus

Author(s): Kostyuchenko, VA (Kostyuchenko, Victor A.); Lim, EXY (Lim, Elisa X. Y.); Zhang, SJ (Zhang, Shuijun); Fibriansah, G (Fibriansah, Guntur); Ng, TS (Ng, Thiam-Seng); Ooi, JSG (Ooi, Justin S. G.); Shi, J (Shi, Jian); Lok, SM (Lok, Shee-Mei)

Source: NATURE  Volume: 533  Issue: 7603  Pages: 425-+  DOI: 10.1038/nature17994  Published: MAY 19 2016  

Times Cited in Web of Science Core Collection: 34

Total Times Cited: 35


Paper 6

Title: Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice

Author(s): Wu, KY (Wu, Kong-Yan); Zuo, GL (Zuo, Guo-Long); Li, XF (Li, Xiao-Feng); Ye, Q (Ye, Qing); Deng, YQ (Deng, Yong-Qiang); Huang, XY (Huang, Xing-Yao); Cao, WC (Cao, Wu-Chun); Qin, CF (Qin, Cheng-Feng); Luo, ZG (Luo, Zhen-Ge)

Source: CELL RESEARCH  Volume: 26  Issue: 6  Pages: 645-654  DOI: 10.1038/cr.2016.58  Published: JUN 2016  

Times Cited in Web of Science Core Collection: 33

Total Times Cited: 33


Paper 7

Title: Characterization of Lethal Zika Virus Infection in AG129 Mice

Author(s): Aliota, MT (Aliota, Matthew T.); Caine, EA (Caine, Elizabeth A.); Walker, EC (Walker, Emma C.); Larkin, KE (Larkin, Katrina E.); Camacho, E (Camacho, Erwin); Osorio, JE (Osorio, Jorge E.)

Source: PLOS NEGLECTED TROPICAL DISEASES  Volume: 10  Issue: 4  Article Number: e0004682  DOI: 10.1371/journal.pntd.0004682  Published: APR 2016  

Times Cited in Web of Science Core Collection: 30

Total Times Cited: 30


Paper 8

Title: A Susceptible Mouse Model for Zika Virus Infection

Author(s): Dowall, SD (Dowall, Stuart D.); Graham, VA (Graham, Victoria A.); Rayner, E (Rayner, Emma); Atkinson, B (Atkinson, Barry); Hall, G (Hall, Graham); Watson, RJ (Watson, Robert J.); Bosworth, A (Bosworth, Andrew); Bonney, LC (Bonney, Laura C.); Kitchen, S (Kitchen, Samantha); Hewson, R (Hewson, Roger)

Source: PLOS NEGLECTED TROPICAL DISEASES  Volume: 10  Issue: 5  Article Number: e0004658  DOI: 10.1371/journal.pntd.0004658  Published: MAY 2016  

Times Cited in Web of Science Core Collection: 25

Total Times Cited: 25


Paper 9

Title: Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody

Author(s): Dai, LP (Dai, Lianpan); Song, J (Song, Jian); Lu, XS (Lu, Xishan); Deng, YQ (Deng, Yong-Qiang); Musyoki, AM (Musyoki, Abednego Moki); Cheng, HJ (Cheng, Huijun); Zhang, YF (Zhang, Yanfang); Yuan, Y (Yuan, Yuan); Song, H (Song, Hao); Haywood, J (Haywood, Joel); Xiao, HX (Xiao, Haixia); Yan, JH (Yan, Jinghua); Shi, Y (Shi, Yi); Qin, CF (Qin, Cheng-Feng); Qi, JX (Qi, Jianxun); Gao, GF (Gao, George F.)

Source: CELL HOST & MICROBE  Volume: 19  Issue: 5  Pages: 696-704  DOI: 10.1016/j.chom.2016.04.013  Published: MAY 11 2016  

Times Cited in Web of Science Core Collection: 23

Total Times Cited: 25


Paper 10

Title: Zika Virus Infects Human Placental Macrophages

Author(s): Quicke, KM (Quicke, Kendra M.); Bowen, JR (Bowen, James R.); Johnson, EL (Johnson, Erica L.); McDonald, CE (McDonald, Circe E.); Ma, HL (Ma, Huailiang); O'Neal, JT (O'Neal, Justin T.); Rajakumar, A (Rajakumar, Augustine); Wrammert, J (Wrammert, Jens); Rimawi, BH (Rimawi, Bassam H.); Pulendran, B (Pulendran, Bali); Schinazi, RF (Schinazi, Raymond F.); Chakraborty, R (Chakraborty, Rana); Suthar, MS (Suthar, Mehul S.)

Source: CELL HOST & MICROBE  Volume: 20  Issue: 1  Pages: 83-90  DOI: 10.1016/j.chom.2016.05.015  Published: JUL 13 2016  

Times Cited in Web of Science Core Collection: 20

Total Times Cited: 20


Paper 11

Title: Structural basis of potent Zika-dengue virus antibody cross-neutralization

Author(s): Barba-Spaeth, G (Barba-Spaeth, Giovanna); Dejnirattisai, W (Dejnirattisai, Wanwisa); Rouvinski, A (Rouvinski, Alexander); Vaney, MC (Vaney, Marie-Christine); Medits, I (Medits, Iris); Sharma, A (Sharma, Arvind); Simon-Loriere, E (Simon-Loriere, Etienne); Sakuntabhai, A (Sakuntabhai, Anavaj); Cao-Lormeau, VM (Cao-Lormeau, Van-Mai); Haouz, A (Haouz, Ahmed); England, P (England, Patrick); Stiasny, K (Stiasny, Karin); Mongkolsapaya, J (Mongkolsapaya, Juthathip); Heinz, FX (Heinz, Franz X.); Screaton, GR (Screaton, Gavin R.); Rey, FA (Rey, Felix A.)

Source: NATURE  Volume: 536  Issue: 7614  Pages: 48-+  DOI: 10.1038/nature18938  Published: AUG 4 2016  

Times Cited in Web of Science Core Collection: 19

Total Times Cited: 19


Paper 12

Title: Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

Author(s): Grant, A (Grant, Alesha); Ponia, SS (Ponia, Sanket S.); Tripathi, S (Tripathi, Shashank); Balasubramaniam, V (Balasubramaniam, Vinod); Miorin, L (Miorin, Lisa); Sourisseau, M (Sourisseau, Marion); Schwarz, MC (Schwarz, Megan C.); Sanchez-Seco, MP (Paz Sanchez-Seco, Mari); Evans, MJ (Evans, Matthew J.); Best, SM (Best, Sonja M.); Garcia-Sastre, A (Garcia-Sastre, Adolfo)

Source: CELL HOST & MICROBE  Volume: 19  Issue: 6  Pages: 882-890  DOI: 10.1016/j.chom.2016.05.009  Published: JUN 8 2016  

Times Cited in Web of Science Core Collection: 18

Total Times Cited: 18


Paper 13

Title: Zika virus damages the human placental barrier and presents marked fetal neurotropism

Author(s): de Noronha, L (de Noronha, Lucia); Zanluca, C (Zanluca, Camila); Azevedo, MLV (Viola Azevedo, Marina Luize); Luz, KG (Luz, Kleber Giovanni); dos Santos, CND (Duarte dos Santos, Claudia Nunes)

Source: MEMORIAS DO INSTITUTO OSWALDO CRUZ  Volume: 111  Issue: 5  Pages: 287-+  DOI: 10.1590/0074-02760160085  Published: MAY 2016  

Times Cited in Web of Science Core Collection: 17

Total Times Cited: 18


Paper 14

Title: Vaccine protection against Zika virus from Brazil

Author(s): Larocca, RA (Larocca, Rafael A.); Abbink, P (Abbink, Peter); Peron, JPS (Peron, Jean Pierre S.); Zanotto, PMD (Zanotto, Paolo M. de A.); Iampietro, MJ (Iampietro, M. Justin); Badamchi-Zadeh, A (Badamchi-Zadeh, Alexander); Boyd, M (Boyd, Michael); Ng'ang'a, D (Ng'ang'a, David); Kirilova, M (Kirilova, Marinela); Nityanandam, R (Nityanandam, Ramya); Mercado, NB (Mercado, Noe B.); Li, ZF (Li, Zhenfeng); Moseley, ET (Moseley, Edward T.); Bricault, CA (Bricault, Christine A.); Borducchi, EN (Borducchi, Erica N.); Giglio, PB (Giglio, Patricia B.); Jetton, D (Jetton, David); Neubauer, G (Neubauer, George); Nkolola, JP (Nkolola, Joseph P.); Maxfield, LF (Maxfield, Lori F.); De La Barrera, RA (De La Barrera, Rafael A.); Jarman, RG (Jarman, Richard G.); Eckels, KH (Eckels, Kenneth H.); Michael, NL (Michael, Nelson L.); Thomas, SJ (Thomas, Stephen J.); Barouch, DH (Barouch, Dan H.)

Source: NATURE  Volume: 536  Issue: 7617  Pages: 474-+  DOI: 10.1038/nature18952  Published: AUG 25 2016  

Times Cited in Web of Science Core Collection: 16

Total Times Cited: 17


Paper 15

Title: A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

Author(s): Barrows, NJ (Barrows, Nicholas J.); Campos, RK (Campos, Rafael K.); Powell, ST (Powell, Steven T.); Prasanth, KR (Prasanth, K. Reddisiva); Schott-Lerner, G (Schott-Lerner, Geraldine); Soto-Acosta, R (Soto-Acosta, Ruben); Galarza-Munoz, G (Galarza-Munoz, Gaddiel); McGrath, EL (McGrath, Erica L.); Urrabaz-Garza, R (Urrabaz-Garza, Rheanna); Gao, JL (Gao, Junling); Wu, P (Wu, Ping); Menon, R (Menon, Ramkumar); Saade, G (Saade, George); Fernandez-Salas, I (Fernandez-Salas, Ildefonso); Rossi, SL (Rossi, Shannan L.); Vasilakis, N (Vasilakis, Nikos); Routh, A (Routh, Andrew); Bradrick, SS (Bradrick, Shelton S.); Garcia-Blanco, MA (Garcia-Blanco, Mariano A.)

Source: CELL HOST & MICROBE  Volume: 20  Issue: 2  Pages: 259-270  DOI: 10.1016/j.chom.2016.07.004  Published: AUG 10 2016  

Times Cited in Web of Science Core Collection: 16

Total Times Cited: 16


Paper 16

Title: Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses

Author(s): Song, H (Song, Hao); Qi, JX (Qi, Jianxun); Haywood, J (Haywood, Joel); Shi, Y (Shi, Yi); Gao, GF (Gao, George F.)

Source: NATURE STRUCTURAL & MOLECULAR BIOLOGY  Volume: 23  Issue: 5  Pages: 456-458  DOI: 10.1038/nsmb.3213  Published: MAY 2016  

Times Cited in Web of Science Core Collection: 15

Total Times Cited: 16


Paper 17

Title: Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission

Author(s): Tabata, T (Tabata, Takako); Petitt, M (Petitt, Matthew); Puerta-Guardo, H (Puerta-Guardo, Henry); Michlmayr, D (Michlmayr, Daniela); Wang, C (Wang, Chunling); Fang-Hoover, J (Fang-Hoover, June); Harris, E (Harris, Eva); Pereira, L (Pereira, Lenore)

Source: CELL HOST & MICROBE  Volume: 20  Issue: 2  Pages: 155-166  DOI: 10.1016/j.chom.2016.07.002  Published: AUG 10 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 13


Paper 18

Title: Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Author(s): Priyamvada, L (Priyamvada, Lalita); Quicke, KM (Quicke, Kendra M.); Hudson, WH (Hudson, William H.); Onlamoon, N (Onlamoon, Nattawat); Sewatanon, J (Sewatanon, Jaturong); Edupuganti, S (Edupuganti, Srilatha); Pattanapanyasat, K (Pattanapanyasat, Kovit); Chokephaibulkit, K (Chokephaibulkit, Kulkanya); Mulligan, MJ (Mulligan, Mark J.); Wilson, PC (Wilson, Patrick C.); Ahmed, R (Ahmed, Rafi); Suthar, MS (Suthar, Mehul S.); Wrammert, J (Wrammert, Jens)

Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  Volume: 113  Issue: 28  Pages: 7852-7857  DOI: 10.1073/pnas.1607931113  Published: JUL 12 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 13


Paper 19

Title: The Viral Polymerase Inhibitor 7-Deaza-2 '-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

Author(s): Zmurko, J (Zmurko, Joanna); Marques, RE (Marques, Rafael E.); Schols, D (Schols, Dominique); Verbeken, E (Verbeken, Erik); Kaptein, SJF (Kaptein, Suzanne J. F.); Neyts, J (Neyts, Johan)

Source: PLOS NEGLECTED TROPICAL DISEASES  Volume: 10  Issue: 5  Article Number: e0004695  DOI: 10.1371/journal.pntd.0004695  Published: MAY 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 13


Paper 20

Title: Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys

Author(s): Abbink, P (Abbink, Peter); Larocca, RA (Larocca, Rafael A.); De La Barrera, RA (De La Barrera, Rafael A.); Bricault, CA (Bricault, Christine A.); Moseley, ET (Moseley, Edward T.); Boyd, M (Boyd, Michael); Kirilova, M (Kirilova, Marinela); Li, ZF (Li, Zhenfeng); Ng'ang'a, D (Ng'ang'a, David); Nanayakkara, O (Nanayakkara, Ovini); Nityanandam, R (Nityanandam, Ramya); Mercado, NB (Mercado, Noe B.); Borducchi, EN (Borducchi, Erica N.); Agarwal, A (Agarwal, Arshi); Brinkman, AL (Brinkman, Amanda L.); Cabral, C (Cabral, Crystal); Chandrashekar, A (Chandrashekar, Abishek); Giglio, PB (Giglio, Patricia B.); Jetton, D (Jetton, David); Jimenez, J (Jimenez, Jessica); Lee, BC (Lee, Benjamin C.); Mojta, S (Mojta, Shanell); Molloy, K (Molloy, Katherine); Shetty, M (Shetty, Mayuri); Neubauer, GH (Neubauer, George H.); Stephenson, KE (Stephenson, Kathryn E.); Peron, JPS (Peron, Jean Pierre S.); Zanotto, PMD (Zanotto, Paolo M. de A.); Misamore, J (Misamore, Johnathan); Finneyfrock, B (Finneyfrock, Brad); Lewis, MG (Lewis, Mark G.); Alter, G (Alter, Galit); Modjarrad, K (Modjarrad, Kayvon); Jarman, RG (Jarman, Richard G.); Eckels, KH (Eckels, Kenneth H.); Michael, NL (Michael, Nelson L.); Thomas, SJ (Thomas, Stephen J.); Barouch, DH (Barouch, Dan H.)

Source: SCIENCE  Volume: 353  Issue: 6304  Pages: 1129-1132  DOI: 10.1126/science.aah6157  Published: SEP 9 2016  

Times Cited in Web of Science Core Collection: 12

Total Times Cited: 12

  

Research front: Identification of bromodomain inhibitors 

Paper 1

Title: Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains

Author(s): Hay, DA (Hay, Duncan A.); Fedorov, O (Fedorov, Oleg); Martin, S (Martin, Sarah); Singleton, DC (Singleton, Dean C.); Tallant, C (Tallant, Cynthia); Wells, C (Wells, Christopher); Picaud, S (Picaud, Sarah); Philpott, M (Philpott, Martin); Monteiro, OP (Monteiro, Octovia P.); Rogers, CM (Rogers, Catherine M.); Conway, SJ (Conway, Stuart J.); Rooney, TPC (Rooney, Timothy P. C.); Tumber, A (Tumber, Anthony); Yapp, C (Yapp, Clarence); Filippakopoulos, P (Filippakopoulos, Panagis); Bunnage, ME (Bunnage, Mark E.); Muller, S (Mueller, Susanne); Knapp, S (Knapp, Stefan); Schofield, CJ (Schofield, Christopher J.); Brennan, PE (Brennan, Paul E.)

Source: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  Volume: 136  Issue: 26  Pages: 9308-9319  DOI: 10.1021/ja412434f  Published: JUL 2 2014  

Times Cited in Web of Science Core Collection: 69

Total Times Cited: 69


Paper 2

Title: Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions

Author(s): Brand, M (Brand, Michael); Measures, AM (Measures, Angelina M.); Wilson, BG (Wilson, Brian G.); Cortopassi, WA (Cortopassi, Wilian A.); Alexander, R (Alexander, Rikki); Hoss, M (Hoess, Matthias); Hewings, DS (Hewings, David S.); Rooney, TPC (Rooney, Timothy P. C.); Paton, RS (Paton, Robert S.); Conway, SJ (Conway, Stuart J.)

Source: ACS CHEMICAL BIOLOGY  Volume: 10  Issue: 1  Pages: 22-39  DOI: 10.1021/cb500996u  Published: JAN 2015  

Times Cited in Web of Science Core Collection: 42

Total Times Cited: 42


Paper 3

Title: LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Author(s): Clark, PGK (Clark, Peter G. K.); Vieira, LCC (Vieira, Lucas C. C.); Tallant, C (Tallant, Cynthia); Fedorov, O (Fedorov, Oleg); Singleton, DC (Singleton, Dean C.); Rogers, CM (Rogers, Catherine M.); Monteiro, OP (Monteiro, Octovia P.); Bennett, JM (Bennett, James M.); Baronio, R (Baronio, Roberta); Muller, S (Mueller, Susanne); Daniels, DL (Daniels, Danette L.); Mendez, J (Mendez, Jacqui); Knapp, S (Knapp, Stefan); Brennan, PE (Brennan, Paul E.); Dixon, DJ (Dixon, Darren J.)

Source: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION  Volume: 54  Issue: 21  Pages: 6217-6221  DOI: 10.1002/anie.201501394  Published: MAY 18 2015  

Times Cited in Web of Science Core Collection: 37

Total Times Cited: 38


Paper 4

Title: Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Author(s): Theodoulou, NH (Theodoulou, Natalie H.); Bamborough, P (Bamborough, Paul); Bannister, AJ (Bannister, Andrew J.); Becher, I (Becher, Isabelle); Bit, RA (Bit, Rino A.); Che, KH (Che, Ka Hing); Chung, CW (Chung, Chun-wa); Dittmann, A (Dittmann, Antje); Drewes, G (Drewes, Gerard); Drewry, DH (Drewry, David H.); Gordon, L (Gordon, Laurie); Grandi, P (Grandi, Paola); Leveridge, M (Leveridge, Melanie); Lindon, M (Lindon, Matthew); Michon, AM (Michon, Anne-Marie); Molnar, J (Molnar, Judit); Robson, SC (Robson, Samuel C.); Tomkinson, NCO (Tomkinson, Nicholas C. O.); Kouzarides, T (Kouzarides, Tony); Prinjha, RK (Prinjha, Rab K.); Humphreys, PG (Humphreys, Philip G.)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1425-1439  DOI: 10.1021/acs.jmedchem.5b00256  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 26

Total Times Cited: 26


Paper 5

Title: Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B

Author(s): Chen, PL (Chen, Peiling); Chaikuad, A (Chaikuad, Apirat); Bamborough, P (Bamborough, Paul); Bantscheff, M (Bantscheff, Marcus); Bountra, C (Bountra, Chas); Chung, CW (Chung, Chun-wa); Fedorov, O (Fedorov, Oleg); Grandi, P (Grandi, Paola); Jung, D (Jung, David); Lesniak, R (Lesniak, Robert); Lindon, M (Lindon, Matthew); Muller, S (Mueller, Susanne); Philpott, M (Philpott, Martin); Prinjha, R (Prinjha, Rab); Rogers, C (Rogers, Catherine); Selenski, C (Selenski, Carolyn); Tallant, C (Tallant, Cynthia); Werner, T (Werner, Thilo); Willson, TM (Willson, Timothy M.); Knapp, S (Knapp, Stefan); Drewry, DH (Drewry, David H.)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1410-1424  DOI: 10.1021/acs.jmedchem.5b00209  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 25

Total Times Cited: 25


Paper 6

Title: The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNFMutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

Author(s): Vangamudi, B (Vangamudi, Bhavatarini); Paul, TA (Paul, Thomas A.); Shah, PK (Shah, Parantu K.); Kost-Alimova, M (Kost-Alimova, Maria); Nottebaum, L (Nottebaum, Lisa); Shi, X (Shi, Xi); Zhan, YA (Zhan, Yanai); Leo, E (Leo, Elisabetta); Mahadeshwar, HS (Mahadeshwar, Harshad S.); Protopopov, A (Protopopov, Alexei); Futreal, A (Futreal, Andrew); Tieu, TN (Tieu, Trang N.); Peoples, M (Peoples, Mike); Heffernan, TP (Heffernan, Timothy P.); Marszalek, JR (Marszalek, Joseph R.); Toniatti, C (Toniatti, Carlo); Petrocchi, A (Petrocchi, Alessia); Verhelle, D (Verhelle, Dominique); Owen, DR (Owen, Dafydd R.); Draetta, G (Draetta, Giulio); Jones, P (Jones, Philip); Palmer, WS (Palmer, Wylie S.); Sharma, S (Sharma, Shikhar); Andersen, JN (Andersen, Jannik N.)

Source: CANCER RESEARCH  Volume: 75  Issue: 18  Pages: 3865-3878  DOI: 10.1158/0008-5472.CAN-14-3798  Published: SEP 15 2015  

Times Cited in Web of Science Core Collection: 23

Total Times Cited: 23


Paper 7

Title: Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

Author(s): Bennett, J (Bennett, James); Fedorov, O (Fedorov, Oleg); Tallant, C (Tallant, Cynthia); Monteiro, O (Monteiro, Octovia); Meier, J (Meier, Julia); Gamble, V (Gamble, Vicky); Savitsky, P (Savitsky, Pavel); Nunez-Alonso, GA (Nunez-Alonso, Graciela A.); Haendler, B (Haendler, Bernard); Rogers, C (Rogers, Catherine); Brennan, PE (Brennan, Paul E.); Muller, S (Mueller, Susanne); Knapp, S (Knapp, Stefan)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1642-1647  DOI: 10.1021/acs.jmedchem.5b00458  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 22

Total Times Cited: 22


Paper 8

Title: Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain Inhibitors

Author(s): Romero, FA (Romero, F. Anthony); Taylor, AM (Taylor, Alexander M.); Crawford, TD (Crawford, Terry D.); Tsui, V (Tsui, Vickie); Cote, A (Cote, Alexandre); Magnuson, S (Magnuson, Steven)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1271-1298  DOI: 10.1021/acs.jmedchem.5b01514  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 21

Total Times Cited: 21


Paper 9

Title: Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

Author(s): Palmer, WS (Palmer, Wylie S.); Poncet-Montange, G (Poncet-Montange, Guillaume); Liu, G (Liu, Gang); Petrocchi, A (Petrocchi, Alessia); Reyna, N (Reyna, Naphtali); Subramanian, G (Subramanian, Govindan); Theroff, J (Theroff, Jay); Yau, A (Yau, Anne); Kost-Alimova, M (Kost-Alimova, Maria); Bardenhagen, JP (Bardenhagen, Jennifer P.); Leo, E (Leo, Elisabetta); Shepard, HE (Shepard, Hannah E.); Tieu, TN (Tieu, Trang N.); Shi, X (Shi, Xi); Zhao, YN (Zhao, Yanai); Zhao, SP (Zhao, Shuping); Barton, MC (Barton, Michelle C.); Draetta, G (Draetta, Giulio); Toniatti, C (Toniatti, Carlo); Jones, P (Jones, Philip); Do, MG (Do, Mary Geck); Andersen, JN (Andersen, Jannik N.)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1440-1454  DOI: 10.1021/acs.jmedchem.5b00405  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 17

Total Times Cited: 18


Paper 10

Title: Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

Author(s): Unzue, A (Unzue, Andrea); Xu, M (Xu, Min); Dong, J (Dong, Jing); Wiedmer, L (Wiedmer, Lars); Spiliotopoulos, D (Spiliotopoulos, Dimitrios); Caflisch, A (Caflisch, Amedeo); Nevado, C (Nevado, Cristina)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1350-1356  DOI: 10.1021/acs.jmedchem.5b00172  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 13


Paper 11

Title: Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

Author(s): Xu, M (Xu, Min); Unzue, A (Unzue, Andrea); Dong, J (Dong, Jing); Spiliotopoulos, D (Spiliotopoulos, Dimitrios); Nevado, C (Nevado, Cristina); Caflisch, A (Caflisch, Amedeo)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 4  Special Issue: SI  Pages: 1340-1349  DOI: 10.1021/acs.jmedchem.5b00171  Published: FEB 25 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 13


Paper 12

Title: Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

Author(s): Martin, LJ (Martin, Laetitia J.); Koegl, M (Koegl, Manfred); Bader, G (Bader, Gerd); Cockcroft, XL (Cockcroft, Xiao-Ling); Fedorov, O (Fedorov, Oleg); Fiegen, D (Fiegen, Dennis); Gerstberger, T (Gerstberger, Thomas); Hofmann, MH (Hofmann, Marco H.); Hohmann, AF (Hohmann, Anja F.); Kessler, D (Kessler, Dirk); Knapp, S (Knapp, Stefan); Knesl, P (Knesl, Petr); Kornigg, S (Kornigg, Stefan); Muller, S (Muller, Susanne); Nar, H (Nar, Herbert); Rogers, C (Rogers, Catherine); Rumpel, K (Rumpel, Klaus); Schaaf, O (Schaaf, Otmar); Steurer, S (Steurer, Steffen); Tallan, C (Tallan, Cynthia); Vakoc, CR (Vakoc, Christopher R.); Zeeb, M (Zeeb, Markus); Zoephel, A (Zoephel, Andreas); Pearson, M (Pearson, Mark); Boehmelt, G (Boehmelt, Guido); McConnell, D (McConnell, Darryl)

Source: JOURNAL OF MEDICINAL CHEMISTRY  Volume: 59  Issue: 10  Pages: 4462-4475  DOI: 10.1021/acs.jmedchem.5b01865  Published: MAY 26 2016  

Times Cited in Web of Science Core Collection: 11

Total Times Cited: 11

  

Research front: Tumor-associated neutrophils and T cell response 

Paper 1

Title: Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

Author(s): Eruslanov, EB (Eruslanov, Evgeniy B.); Bhojnagarwala, PS (Bhojnagarwala, Pratik S.); Quatromoni, JG (Quatromoni, Jon G.); Stephen, TL (Stephen, Tom Li); Ranganathan, A (Ranganathan, Anjana); Deshpande, C (Deshpande, Charuhas); Akimova, T (Akimova, Tatiana); Vachani, A (Vachani, Anil); Litzky, L (Litzky, Leslie); Hancock, WW (Hancock, Wayne W.); Conejo-Garcia, JR (Conejo-Garcia, Jose R.); Feldman, M (Feldman, Michael); Albeida, SM (Albeida, Steven M.); Singhal, S (Singhal, Sunil)

Source: JOURNAL OF CLINICAL INVESTIGATION  Volume: 124  Issue: 12  Pages: 5466-5480  DOI: 10.1172/JCI7053  Published: DEC 2014  

Times Cited in Web of Science Core Collection: 63

Total Times Cited: 64


Paper 2

Title: Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Author(s): Wculek, SK (Wculek, Stefanie K.); Malanchi, I (Malanchi, Ilaria)

Source: NATURE  Volume: 528  Issue: 7582  Pages: 413-+  DOI: 10.1038/nature16140  Published: DEC 17 2015  

Times Cited in Web of Science Core Collection: 48

Total Times Cited: 50


Paper 3

Title: Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils

Author(s): Casbon, AJ (Casbon, Amy-Jo); Reynaud, D (Reynaud, Damien); Park, C (Park, Chanhyuk); Khuc, E (Khuc, Emily); Gan, DD (Gan, Dennis D.); Schepers, K (Schepers, Koen); Passegue, E (Passegue, Emmanuelle); Werb, Z (Werb, Zena)

Source: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA  Volume: 112  Issue: 6  Pages: E566-E575  DOI: 10.1073/pnas.1424927112  Published: FEB 10 2015  

Times Cited in Web of Science Core Collection: 36

Total Times Cited: 36


Paper 4

Title: MET is required for the recruitment of anti-tumoural neutrophils

Author(s): Finisguerra, V (Finisguerra, Veronica); Di Conza, G (Di Conza, Giusy); Di Matteo, M (Di Matteo, Mario); Serneels, J (Serneels, Jens); Costa, S (Costa, Sandra); Thompson, AAR (Thompson, A. A. Roger); Wauters, E (Wauters, Els); Walmsley, S (Walmsley, Sarah); Prenen, H (Prenen, Hans); Granot, Z (Granot, Zvi); Casazza, A (Casazza, Andrea); Mazzone, M (Mazzone, Massimiliano)

Source: NATURE  Volume: 522  Issue: 7556  Pages: 349-+  DOI: 10.1038/nature14407  Published: JUN 18 2015  

Times Cited in Web of Science Core Collection: 34

Total Times Cited: 34


Paper 5

Title: Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

Author(s): Mandruzzato, S (Mandruzzato, Susanna); Brandau, S (Brandau, Sven); Britten, CM (Britten, Cedrik M.); Bronte, V (Bronte, Vincenzo); Damuzzo, V (Damuzzo, Vera); Gouttefangeas, C (Gouttefangeas, Cecile); Maurer, D (Maurer, Dominik); Ottensmeier, C (Ottensmeier, Christian); van der Burg, SH (van der Burg, Sjoerd H.); Welters, MJP (Welters, Marij J. P.); Walter, S (Walter, Steffen)

Source: CANCER IMMUNOLOGY IMMUNOTHERAPY  Volume: 65  Issue: 2  Pages: 161-169  DOI: 10.1007/s00262-015-1782-5  Published: FEB 2016  

Times Cited in Web of Science Core Collection: 16

Total Times Cited: 16


Paper 6

Title: Neutrophils in the Tumor Microenvironment

Author(s): Powell, DR (Powell, Davalyn R.); Huttenlocher, A (Huttenlocher, Anna)

Source: TRENDS IN IMMUNOLOGY  Volume: 37  Issue: 1  Pages: 41-52  DOI: 10.1016/j.it.2015.11.008  Published: JAN 2016  

Times Cited in Web of Science Core Collection: 14

Total Times Cited: 14


Paper 7

Title: Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

Author(s): Andzinski, L (Andzinski, Lisa); Kasnitz, N (Kasnitz, Nadine); Stahnke, S (Stahnke, Stephanie); Wu, CF (Wu, Ching-Fang); Gereke, M (Gereke, Marcus); von Kockritz-Blickwede, M (von Koeckritz-Blickwede, Maren); Schilling, B (Schilling, Bastian); Brandau, S (Brandau, Sven); Weiss, S (Weiss, Siegfried); Jablonska, J (Jablonska, Jadwiga)

Source: INTERNATIONAL JOURNAL OF CANCER  Volume: 138  Issue: 8  Pages: 1982-1993  DOI: 10.1002/ijc.29945  Published: APR 15 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 14


Paper 8

Title: The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

Author(s): Liang, W (Liang, Wei); Ferrara, N (Ferrara, Napoleone)

Source: CANCER IMMUNOLOGY RESEARCH  Volume: 4  Issue: 2  Pages: 83-91  DOI: 10.1158/2326-6066.CIR-15-0313  Published: FEB 2016  

Times Cited in Web of Science Core Collection: 13

Total Times Cited: 14


Paper 9

Title: Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells

Author(s): Spiegel, A (Spiegel, Asaf); Brooks, MW (Brooks, Mary W.); Houshyar, S (Houshyar, Samin); Reinhardt, F (Reinhardt, Ferenc); Ardolino, M (Ardolino, Michele); Fessler, E (Fessler, Evelyn); Chen, MB (Chen, Michelle B.); Krall, JA (Krall, Jordan A.); DeCock, J (DeCock, Jasmine); Zervantonakis, IK (Zervantonakis, Ioannis K.); Iannello, A (Iannello, Alexandre); Iwamoto, Y (Iwamoto, Yoshiko); Cortez-Retamozo, V (Cortez-Retamozo, Virna); Kamm, RD (Kamm, Roger D.); Pittet, MJ (Pittet, Mikael J.); Raulet, DH (Raulet, David H.); Weinberg, RA (Weinberg, Robert A.)

Source: CANCER DISCOVERY  Volume: 6  Issue: 6  Pages: 630-649  DOI: 10.1158/2159-8290.CD-15-1157  Published: JUN 2016  

Times Cited in Web of Science Core Collection: 10

Total Times Cited: 10

  

Research front: Transmission and persistence of Ebola virus 

Paper 1

Title: Persistence of Ebola Virus in Ocular Fluid during Convalescence

Author(s): Varkey, JB (Varkey, Jay B.); Shantha, JG (Shantha, Jessica G.); Crozier, I (Crozier, Ian); Kraft, CS (Kraft, Colleen S.); Lyon, GM (Lyon, G. Marshall); Mehta, AK (Mehta, Aneesh K.); Kumar, G (Kumar, Gokul); Smith, JR (Smith, Justine R.); Kainulainen, MH (Kainulainen, Markus H.); Whitmer, S (Whitmer, Shannon); Stroher, U (Stroeher, Ute); Uyeki, TM (Uyeki, Timothy M.); Ribner, BS (Ribner, Bruce S.); Yeh, S (Yeh, Steven)

Source: NEW ENGLAND JOURNAL OF MEDICINE  Volume: 372  Issue: 25  Pages: 2423-2427  DOI: 10.1056/NEJMoa1500306  Published: JUN 18 2015  

Times Cited in Web of Science Core Collection: 94

Total Times Cited: 94


Paper 2

Title: Molecular Evidence of Sexual Transmission of Ebola Virus

Author(s): Mate, SE (Mate, S. E.); Kugelman, JR (Kugelman, J. R.); Nyenswah, TG (Nyenswah, T. G.); Ladner, JT (Ladner, J. T.); Wiley, MR (Wiley, M. R.); Cordier-Lassalle, T (Cordier-Lassalle, T.); Christie, A (Christie, A.); Schroth, GP (Schroth, G. P.); Gross, SM (Gross, S. M.); Davies-Wayne, GJ (Davies-Wayne, G. J.); Shinde, SA (Shinde, S. A.); Murugan, R (Murugan, R.); Sieh, SB (Sieh, S. B.); Badio, M (Badio, M.); Fakoli, L (Fakoli, L.); Taweh, F (Taweh, F.); de Wit, E (de Wit, E.); van Doremalen, N (van Doremalen, N.); Munster, VJ (Munster, V. J.); Pettitt, J (Pettitt, J.); Prieto, K (Prieto, K.); Humrighouse, BW (Humrighouse, B. W.); Stroher, U (Stroeher, U.); DiClaro, JW (DiClaro, J. W.); Hensley, LE (Hensley, L. E.); Schoepp, RJ (Schoepp, R. J.); Safronetz, D (Safronetz, D.); Fair, J (Fair, J.); Kuhn, JH (Kuhn, J. H.); Blackley, DJ (Blackley, D. J.); Laney, AS (Laney, A. S.); Williams, DE (Williams, D. E.); Lo, T (Lo, T.); Gasasira, A (Gasasira, A.); Nichol, ST (Nichol, S. T.); Formenty, P (Formenty, P.); Kateh, FN (Kateh, F. N.); De Cock, KM (De Cock, K. M.); Bolay, F (Bolay, F.); Sanchez-Lockhart, M (Sanchez-Lockhart, M.); Palacios, G (Palacios, G.)

Source: NEW ENGLAND JOURNAL OF MEDICINE  Volume: 373  Issue: 25  Pages: 2448-2454  DOI: 10.1056/NEJMoa1509773  Published: DEC 17 2015  

Times Cited in Web of Science Core Collection: 60

Total Times Cited: 61


Paper 3

Title: Possible Sexual Transmission of Ebola Virus - Liberia, 2015

Author(s): Christie, A (Christie, Athalia); Davies-Wayne, GJ (Davies-Wayne, Gloria J.); Cordier-Lasalle, T (Cordier-Lasalle, Thierry); Blackley, DJ (Blackley, David J.); Laney, AS (Laney, A. Scott); Williams, DE (Williams, Desmond E.); Shinde, SA (Shinde, Shivam A.); Badio, M (Badio, Moses); Lo, T (Lo, Terrence); Mate, SE (Mate, Suzanne E.); Ladner, JT (Ladner, Jason T.); Wiley, MR (Wiley, Michael R.); Kugelman, JR (Kugelman, Jeffrey R.); Palacios, G (Palacios, Gustavo); Holbrook, MR (Holbrook, Michael R.); Janosko, KB (Janosko, Krisztina B.); de Wit, E (de Wit, Emmie); van Doremalen, N (van Doremalen, Neeltje); Munster, VJ (Munster, Vincent J.); Pettitt, J (Pettitt, James); Schoepp, RJ (Schoepp, Randal J.); Verhenne, L (Verhenne, Leen); Evlampidou, I (Evlampidou, Iro); Kollie, KK (Kollie, Karsor K.); Sieh, SB (Sieh, Sonpon B.); Gasasira, A (Gasasira, Alex); Bolay, F (Bolay, Fatorma); Kateh, FN (Kateh, Francis N.); Nyenswah, TG (Nyenswah, Tolbert G.); De Cock, KM (De Cock, Kevin M.)

Source: MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT  Volume: 64  Issue: 17  Pages: 479-481  Published: MAY 8 2015  

Times Cited in Web of Science Core Collection: 53

Total Times Cited: 55


Paper 4

Title: Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study

Author(s): Clark, DV (Clark, Danielle V.); Kibuuka, H (Kibuuka, Hannah); Millard, M (Millard, Monica); Wakabi, S (Wakabi, Salim); Lukwago, L (Lukwago, Luswa); Taylor, A (Taylor, Alison); Eller, MA (Eller, Michael A.); Eller, LA (Eller, Leigh Anne); Michael, NL (Michael, Nelson L.); Honko, AN (Honko, Anna N.); Olinger, GG (Olinger, Gene G., Jr.); Schoepp, RJ (Schoepp, Randal J.); Hepburn, MJ (Hepburn, Matthew J.); Hensley, LE (Hensley, Lisa E.); Robb, ML (Robb, Merlin L.)

Source: LANCET INFECTIOUS DISEASES  Volume: 15  Issue: 8  Pages: 905-912  DOI: 10.1016/S1473-3099(15)70152-0  Published: AUG 2015  

Times Cited in Web of Science Core Collection: 42

Total Times Cited: 42


Paper 5

Title: Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study

Author(s): Mattia, JG (Mattia, John G.); Vandy, MJ (Vandy, Mathew J.); Chang, JC (Chang, Joyce C.); Platt, DE (Platt, Devin E.); Dierberg, K (Dierberg, Kerry); Bausch, DG (Bausch, Daniel G.); Brooks, T (Brooks, Tim); Conteh, S (Conteh, Sampha); Crozier, I (Crozier, Ian); Fowler, RA (Fowler, Robert A.); Kamara, AP (Kamara, Amadu P.); Kang, C (Kang, Cindy); Mahadevan, S (Mahadevan, Srividya); Mansaray, Y (Mansaray, Yealie); Marcell, L (Marcell, Lauren); McKay, G (McKay, Gillian); O'Dempsey, T (O'Dempsey, Tim); Parris, V (Parris, Victoria); Pinto, R (Pinto, Ruxandra); Rangel, A (Rangel, Audrey); Salam, AP (Salam, Alex P.); Shantha, J (Shantha, Jessica); Wolfman, V (Wolfman, Vanessa); Yeh, S (Yeh, Steven); Chan, AK (Chan, Adrienne K.); Mishra, S (Mishra, Sharmistha)

Source: LANCET INFECTIOUS DISEASES  Volume: 16  Issue: 3  Pages: 331-338  DOI: 10.1016/S1473-3099(15)00489-2  Published: MAR 2016  

Times Cited in Web of Science Core Collection: 20

Total Times Cited: 20


Paper 6

Title: Systematic review of the literature on viral persistence and sexual transmission from recovered Ebola survivors: evidence and recommendations

Author(s): Thorson, A (Thorson, Anna); Formenty, P (Formenty, Pierre); Lofthouse, C (Lofthouse, Clare); Broutet, N (Broutet, Nathalie)

Source: BMJ OPEN  Volume: 6  Issue: 1  Article Number: e008859  DOI: 10.1136/bmjopen-2015-008859  Published: 2016  

Times Cited in Web of Science Core Collection: 10

Total Times Cited: 10

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