Hot papers in pharmacology and toxicology

	Paper Author(s), Journal	Citations
1	Interfering with disease: A progress report on siRNA-based therapeutics A. de Fougerolles, H.%u2009P. Vornlocher, J. Maraganore et al Nature Reviews Drug Discovery, 6(6):443-53, June 2007	101
2	Transvascular delivery of small interfering RNA to the central nervous system P. Kumar, H.%u2009Q. Wu, J.%u2009L. McBride et al Nature, 448(7149):39-43, July 2007	90
3	Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics C. Szabo, H. Ischiropoulos and R. Radi Nature Reviews Drug Discovery, 6(8):662-680 August 2007	89
4	The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept A. Szallasi, D.%u2009N. Cortright, C.%u2009A. Blum et al Nature Reviews Drug Discovery, 6(5):357-372 May 2007	88
5	Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators C.%u2009T. Supuran Nature Reviews Drug Discovery, 7(2):168-181 February 2008	64

The data above were extracted from Thomson Reuters Essential Science Indicators database. This database, currently covering the period January 1999 through April 2009, surveys only journal articles (original research reports and review articles) indexed by Thomson Reuters. Articles are assigned to a category based on the journals in which they were published and the journal-to-category field-definition scheme used by Thomson Reuters. Hot papers are limited to those articles published in the last two years. A paper is selected as a hot paper if it meets a citation-frequency threshold determined for its field and bi-monthly group. Citation-frequency distributions are compiled for each field and cohort. Thresholds are set by finding the closest citation count that would select the top fraction of papers in each field and period. The fraction is set to retrieve about 0.1 per cent of papers. For more information on Essential Science Indicators, see http://scientific.thomsonreuters.com/ products/esi