Brussels, 06 Oct 2005
The European Commission's Joint Research Centre (JRC) has published a call for tenders for research and experimental services in the field of 'in vitro' blood-brain barrier models.
The aim of the study is to evaluate the performance of the most promising BBB 'in vitro' models discussed during the ECVAM workshop (primary bovine endothelial cells co-cultured with rat primary astrocytes; porcine primary endothelial cells cultured in hydrocortisone-conditioned medium; the ARPE-19 human retinal cell line co-cultured with a human glioma cell line; GPNT cells and MDCKmdr-1 cells) by testing 10-20 compounds representing low, medium and high passage and measuring the barrier integrity and the rates of transport for each compound at the no-observed-effect level (NOEL) or the lowest-observed-effect level (LOEL) concentrations.
The ultimate goal of this project is to identify the best model or battery of models and to combine all the information obtained for use in an appropriate biokinetic model that should enter a validation study.
For further information, please contact:
Joint Research Centre, Institute for Health and Consumer Protection, Management Support Unit
Attn: Silvia Bottini
Via E. Fermi 1
I-21020 Ispra (Varese)
Tel. (39) 03 32 78 58 19
Fax (39) 03 32 78 94 34
To see the full details of the call, please consult the following web address:
http:///t ed.publications.eu.int/udl?REQUE ST=Seek-Deliver&LANGUAGE=en&DOCI D=189737-2005
Remarks: The deadline for requesting tender documents is 17.10.2005.
The deadline for submitting tender documents is 7.11.2005.
Before contacting the Commission, tenderers are strongly advised to consult the original call text in the Official Journal of the European Union at the reference below.