Addictive cannabis

四月 24, 1998

Professor Heather Ashton does us a considerable service by drawing attention to the much-neglected adverse properties of cannabis ("From hashish to ashes?" THES, April 17).

Recent basic research, which directly complements Professor Ashton's clinical experience, has proved convincingly that cannabis is a drug of dependence.

Neuroscientific studies showed initially that we have within our brains receptors with 3-D specificity for cannabis and also endogenous cannabis-like neurotransmitters similar to serotonin and dopamine. Thus, taking cannabis will inevitably disrupt our endogenous cannabis systems.

Evidence for this comes from studies (Aceto et al, Journal of Pharmacology and Experimental Therapeutics, 1996, 8: 1290-1295) in which rats were treated with cannabis for four days only. This caused the endogenous cannabis system to adapt in order to minimise the effects of the administered cannabis.

The rats were then given a recently developed specific cannabis antagonist drug. This rapidly displaced cannabis from its receptors and "precipitated" a withdrawal syndrome involving abnormal gross movements, shaking and muscle spasms.

Similar effects are seen with opiates (such as heroin and morphine) in animals treated with specific opiate antagonists after opiate experience, which interferes with the functioning of endogenous opiates or "endorphine".

These results show unequivocally that cannabis is a drug of dependence and suggest that its "addictive" properties have been underestimated.

Given the widespread use of cannabis among students, this is cause for considerable concern for all in higher education and a very clear reason for not decriminalising cannabis and marijuana.

Andrew Goudie Reader in psychopharmacology University of Liverpool

登录 或者 注册 以便阅读全文。

请先注册再进行下一步

获得一个月的无限制地在线阅读网站内容。只需注册并完成您的职业简介.

注册是免费的,而且非常简单。一旦成功注册,您可以每个月免费阅读3篇文章。:

  • 获得编辑推荐文章
  • 率先获得泰晤士高等教育世界大学排名相关的新闻
  • 获得职位推荐、筛选工作和保存工作搜索结果
  • 参与读者讨论和公布评论
注册

欢迎反馈

Log in or register to post comments

评论最多