Hot papers in immunology

	Paper, Author(s), journal	Citations
1	IL-17 and Th17 Cells Thomas Korn, Estelle Bettelli, Mohamed Oukka and Vijay K. Kuchroo Annual Review of Immunology, : 485-517, 2009	77
2	Late Developmental Plasticity in the T Helper 17 Lineage Yun Kyung Lee, Henrietta Turner, Craig L. Maynard, James R. Oliver, Dongquan Chen, Charles O. Elson and Casey T. Weaver Immunity, 30(1): 92-107, 16 January 2009	65
3	Global Mapping of H3K4me3 and H3Kme3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells Gang Wei, Lai Wei, Jinfang Zhu, Chongzhi Zang, Jane Hu-Li, Zhengju Yao, Kairong Cui, Yuka Kanno, Tae-Young Roh, Wendy T. Watford, Dustin E. Schones, Weiqun Peng, Hong-wei Sun, William E. Paul, John J. O’Shea and Keji Zhao Immunity, 30(1): 155-167, 16 January 2009	55
4	Plasticity of CD4+ T Cell Lineage Differentiation Liang Zhou, Mark M.%u2009W. Chong and Dan R. Littman Immunity, 30(5): 646-655, 22 May 2009	46
5	The Inflammasome: a Caspase-1 Activation Platform that Regulates Immune Responses and Disease Pathogenesis Luigi Franchi, Tatjana Eigenbrod, Raul Munoz-Planillo and Gabriel Nunez Nature Immunology, 10(3): 241-247, March 2009	43
6	C-C Chemokine Receptor 6-Regulated Entry of TH-17 Cells into the CNS through the Choroid Plexus is Required for the Initiation of EAE Andrea Reboldi, Caroline Coisne, Dirk Baumjohann, Federica Benvenuto, Denise Bottinelli, Sergio Lira, Antonio Uccelli, Antonio Lanzavecchia, Britta Engelhardt and Federica Sallusto Nature Immunology, 10(5): 514-523, May 2009	30
7	Instability of the Transcription Factor Foxp3 Leads to the Generation of Pathogenic Memory T Cells in vivo Xuyu Zhou, Samantha L. Bailey-Bucktrout, Lukas T. Jeker, Cristina Penaranda, Marc Martinez-Llordella, Meredith Ashby, Maki Nakayama, Wendy Rosenthal and Jeffrey A. Bluestone Nature Immunology, 10(9): 1000-1007, September 2009	22

The data above were extracted from the Thomson Reuters Essential Science Indicators database. This database, currently covering the period January 1999 to December 2009, surveys only journal articles (original research reports and review articles) indexed by Thomson Reuters. Articles are assigned to a category based on the journals in which they were published and Thomson Reuters’ journal-to-category field-definition scheme.

“Hot papers” are limited to those articles published in the past two years. A paper is selected as a hot paper if it meets a citation frequency threshold determined for its field and bimonthly group. Citation frequency distributions are compiled for each field and cohort. Thresholds are set by finding the closest citation count that would select the top fraction of papers in each field and period. The fraction is set to retrieve about 0.1 per cent of papers. Featured here are the immunology papers published in 2009 that have already qualified as hot papers. Most were published in the first half of the year, since citations take some time to accumulate. Still, the paper ranked seventh appeared as recently as September 2009 and has quickly achieved hot paper status.

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