Research Fellow in Structural Biology

Leeds, United Kingdom
£33,797 to £40,322 p.a
09 Mar 2020
02 Apr 2020
Fixed Term
Full Time

Are you looking to apply your skills in Structural Biology and Imaging to gain a new molecular understanding of the structure of amyloid fibrils and help to develop new routes to combat amyloid diseases?

We are looking for an outstanding postdoctoral research fellow to join our well-established interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils and the link between disease-relevant mutations and post-translational modifications and fibril structure. This MRC-funded position is to use cryoEM together with a other biophysical techniques to determine the structures of amyloid fibrils, especially fibrils purified from patient samples. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid fibril structure and the consequences of these differences in cellular function and disease. 

You will be based in the laboratories of Professor Neil Ranson & Professor Sheena Radford, and work closely with our clinically-qualified collaborators and other members of the amyloid team (funded by BBSRC, MRC and Wellcome). You will have a PhD (or be close completion) in Structural Biology, Biochemistry, Imaging or a related discipline with substantial experience in using cryo-electron microscopy/tomography to determine the 3D structures of protein complexes.

Further information about the project and our recent publications are available within the additional information document.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017.  We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information. 

To explore the post further or for any queries you may have, please contact: 

Professor Neil A Ranson, Professor of Structural Molecular Biology 
Tel: +44 (0)113 343 7065, Email:


Professor Sheena Radford, Astbury Professor of Biophysics
Tel: +44 (0)113 343 3170, Email:

Location:  Leeds - Main Campus
Faculty/Service:  Faculty of Biological Sciences
School/Institute:  School of Molecular & Cellular Biology / Astbury Centre for Structural Molecular Biology
Category:  Research
Grade:  Grade 7
Salary:  £33,797 to £40,322 p.a.   Due to funding limitations it is unlikely an appointment will be made above £38,017
Post Type:  Full Time
Contract Type:  Fixed Term (3 Years)    
Closing Date:  Thursday 02 April 2020
Reference:  FBSAS1029
Downloads:  Candidate Brief   Additional Information