Starting Salary Range: $14.00 - $19.25
Employee group: Full Time
Employee subgroup: Salaried Non-exmt
Location: 725 N. Wolfe Street
Department name: 10002806-SOM DOM Clinical Pharmacology
Personnel area: School of Medicine
Technical support is needed for a small research group with a longstanding focus on the development of new treatments for tropical diseases. This includes the identification of new drug targets, testing of newly synthesized compounds for activity against malaria parasites and trypanosomes, and study of the impact of pharmacokinetics on drug efficacy. Standard techniques of molecular pharmacology, molecular biology, and biochemistry are utilized, as are more innovative approaches with, for example, dynamic in vitro PK/PD and quantitative mass spectrometry.
Duties & Responsibilities
- Maintain Plasmodium falciparum (malaria parasites), Trypanosoma brucei (African trypanosomes), and some mammalian cells in tissue culture; prepare stabilates
- Test compounds in vitro in microtiter plate assay against malaria parasites, trypanosomes or mammalian cells
- Maintain, sterilize, assemble and run in vitro cartridge system for determining pharmacokinetic/pharmacodynamic (PK/PD) relationships
- Transfer ~25 lb PK/PD apparatus from incubator to sterile cabinet and back
- Design and run 3-cartridge PK/PD studies with malaria parasites and African trypanosomes
- Determine drug concentrations by radiolabeled tracer or bioassay
- Contribute to general lab maintenance: maintain orderly and clean workspace, order and inventory supplies, prepare stock solutions, autoclave supplies, help with disposal of biohazardous waste
- Compile, process and record data; cross validate data before publication
- Present results at lab meetings, contribute to writing manuscripts for publication
- Maintain lab methods books and inventory of stabilates
- Create first draft for lab methods document
Bachelor’s degree in biology, chemistry, or related field required
Some related post-undergraduate work experience preferred.
Special knowledge, skills, and abilities
- Experiments involve use of human pathogens, human tissues and radioisotopes.
- Experience with cell culture strongly preferred; meticulous sterile technique will be essential in this job. Experience with computer spread sheets, graphics, word processing required. Must be accurate and neat in work. Must be reliable and willing to learn new skills.
- Must like and be good at basic math: able reliably to calculate molar solutions and to utilize pre-designed spreadsheets to obtain pharmacokinetic parameters. Prefer, but do not require, experience in handling animals and radioisotopes; familiarity with small molecule quantitation by liquid chromatography-mass spectrometry would be advantageous.
- Must have the interest and ability to tackle new, sometimes challenging, projects. This job requires the ability to maintain an orderly lab environment, and a cooperative nature that supports multiple lab users and new trainees.
The successful candidate(s) for this position will be subject to a pre-employment background check.
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During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.
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