Research Technologist

Location
Maryland, United States
Salary
$14.00 - $19.25
Posted
02 Oct 2018
End of advertisement period
02 Dec 2018
Ref
11423
Contract Type
Permanent
Hours
Full Time

Role/Level/Range: ACRO40/E/02/CC 
Starting Salary Range: $14.00 - $19.25
Employee group: Full Time 
Schedule: 8:30-5pm 
Employee subgroup: Salaried Non-exmt 
Location: 725 N. Wolfe Street 
Department name: 10002806-SOM DOM Clinical Pharmacology 
Personnel area: School of Medicine

General Summary

Technical support is needed for a small research group with a longstanding focus on the development of new treatments for tropical diseases.  This includes the identification of new drug targets, testing of newly synthesized compounds for activity against malaria parasites and trypanosomes, and study of the impact of pharmacokinetics on drug efficacy.  Standard techniques of molecular pharmacology, molecular biology, and biochemistry are utilized, as are more innovative approaches with, for example, dynamic in vitro PK/PD and quantitative mass spectrometry.

Duties & Responsibilities

  • Maintain Plasmodium falciparum (malaria parasites), Trypanosoma brucei (African trypanosomes), and some mammalian cells in tissue culture; prepare stabilates
  • Test compounds in vitro in microtiter plate assay against malaria parasites, trypanosomes or mammalian cells
  • Maintain, sterilize, assemble and run in vitro cartridge system for determining pharmacokinetic/pharmacodynamic (PK/PD) relationships
  • Transfer ~25 lb PK/PD apparatus from incubator to sterile cabinet and back
  • Design and run 3-cartridge PK/PD studies with malaria parasites and African trypanosomes
  • Determine drug concentrations by radiolabeled tracer or bioassay
  • Contribute to general lab maintenance: maintain orderly and clean workspace, order and inventory supplies, prepare stock solutions, autoclave supplies, help with disposal of biohazardous waste
  • Compile, process and record data; cross validate data before publication
  • Present results at lab meetings, contribute to writing manuscripts for publication
  • Maintain lab methods books and inventory of stabilates
  • Create first draft for lab methods document

Qualifications

Bachelor’s degree in biology, chemistry, or related field required

Preferred qualifications

Some related post-undergraduate work experience preferred.

Special knowledge, skills, and abilities

  • Experiments involve use of human pathogens, human tissues and radioisotopes. 
  • Experience with cell culture strongly preferred; meticulous sterile technique will be essential in this job. Experience with computer spread sheets, graphics, word processing required.  Must be accurate and neat in work.  Must be reliable and willing to learn new skills.  
  • Must like and be good at basic math: able reliably to calculate molar solutions and to utilize pre-designed spreadsheets to obtain pharmacokinetic parameters.  Prefer, but do not require, experience in handling animals and radioisotopes; familiarity with small molecule quantitation by liquid chromatography-mass spectrometry would be advantageous.
  • Must have the interest and ability to tackle new, sometimes challenging, projects.  This job requires the ability to maintain an orderly lab environment, and a cooperative nature that supports multiple lab users and new trainees.

The successful candidate(s) for this position will be subject to a pre-employment background check.

If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at jhurecruitment@jhu.edu. For TTY users, call via Maryland Relay or dial 711.

The following additional provisions may apply depending on which campus you will work.  Your recruiter will advise accordingly.

During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.

The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.

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