Research Technologist

Maryland, United States
$13.73 - $18.87
20 Sep 2018
End of advertisement period
20 Nov 2018
Contract Type
Full Time

General Summary/Purpose

Cryptococcal meningitis is a serious infection in the Central Nervous System caused by the yeast Cryptococcus neoformans. Diagnostic tests and clinical outcomes of infected patients are mainly determined by the Cryptococcal antigen (CrAg). The CrAg is a polysaccharide secreted in the cerebrospinal fluid of patients causing multiple deleterious immunological effects. Despite its importance in disease, no structural information is available on the CrAg produced during human infection. A better understanding of the CrAg structure produced in humans will help us understand the disease, predict clinical outcomes, and develop better diagnostic and vaccination strategies against Cryptococcal meningitis.

The Casadevall laboratory seeks an individual to conduct research on the isolation and characterization of the CrAg contained in the CSF of infected patients. The research involves a variety of biochemical and biophysical methodologies, including: enzyme-linked immunosorbent assay, chromatography, ultrafiltration and solution light scattering.

Specific Duties & Responsibilities

  • Develop and follow procedures to isolate and characterize the Cryptococcal antigen from cerebrospinal fluids of patients (ie. enzyme-linked immunosorbent assay, chromatography, ultrafiltration and solution light scattering).
  • Perform laboratory experiments by following common protocols or with instruction.
  • Gain problem solving-skills through progressive training, understanding of the research, and experience.
  • Set-up experiments based on defined standards.
  • Identify and resolves common problems involved in routine research assays. Understand the role of senior lab members and accept constructive guidance. Increase own skill base and knowledge of lab research and relevant assays.
  • Set-up experiments based on defined standards.
  • Practice aseptic techniques during experimentation
  • Keep careful data collection and record of all experiments performed.
  • Perform related laboratory maintenance, monitoring inventory of supplies, cleaning equipment.

Minimum Qualifications

  • Bachelor's degree in biology, chemistry or related field.

Preferred Qualifications

  • Some related post-undergraduate work experience preferred.
  • Experience with any of the biochemical and biophysical techniques described above, experimental design and data interpretation.
  • Experience with basic laboratory instrumentation and basic science knowledge to learn techniques/methods of the laboratory.
  • Positive attitude, desire to learn and proactivity.

Classified title: Research Technologist
Role/Level/Range: ACRO2/CC
Hourly Rate Range: $13.73 - $18.87; commensurate with experience
Employee group: Casual
Employee subgroup: Non-exempt
Schedule: 27 hrs/week or less
Department Name: Molecular Microbiology and Immunology
Personnel Area: School of Public Health

The successful candidate(s) for this position will be subject to a pre-employment background check.

If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the HR Business Services Office at For TTY users, call via Maryland Relay or dial 711.

The following additional provisions may apply depending on which campus you will work. Your recruiter will advise accordingly.

During the Influenza ("the flu") season, as a condition of employment, The Johns Hopkins Institutions require all employees who provide ongoing services to patients or work in patient care or clinical care areas to have an annual influenza vaccination or possess an approved medical or religious exception. Failure to meet this requirement may result in termination of employment.

The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.

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