Research Associate in Single-Molecule Biophysics

Bristol , City of Bristol (GB)
£32,548 - £36,613 per annum
18 Jul 2018
End of advertisement period
17 Aug 2018
Academic Discipline
Physical Sciences, Physics & Astronomy
Contract Type
Fixed Term
Full Time

EPICut project: Two postdoc positions are available following the award of a prestigious 5-year ERC advanced grant to Prof. Mark Szczelkun. The ambition of the EPICut project is to understand: the structural and mechanistic basis for how a diverse set of prokaryotic Type IV restriction systems cleave epigenetic modifications on mobile genetic elements such as phage; how these immune systems influence bacteria at the level of individual cells, populations and communities; and to further exploit these enzymes as tools for recognition of epigenetic markers.

Research Associate in Single-Molecule Biophysics post: we are looking for a talented and enthusiastic individual who can use single molecule microscopy techniques to investigate the mechanisms of modified DNA recognition and cleavage. You will join an established and well-funded research lab in the DNA-Protein Interactions Unit, with access to TIRF, optical tweezers and magnetic tweezers microscopes. The role will involve the day-to-day project management, assisting with training and supervision of postgraduate/undergraduate students, and collaborations with other members of the EPICut project.

A PhD in protein biochemistry, biophysics, or a related subject is essential (awarded or imminent). Previous experience in the analysis of protein-DNA interactions or other biological systems using single-molecule microscopy, and/or in the construction of microscopes, is desirable. You will be highly organised, and eager to learn new skills and to interact with a broad range of colleagues. Funding is available for 5 years in the first instance.
For informal enquiries, please contact Mark Szczelkun on or (0117) 33 12158.

The University is committed to creating and sustaining a fully inclusive culture. We welcome applicants from all backgrounds and communities. 

Similar jobs

Similar jobs