NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY -NTNU

PhD Research Fellowship in Tissue Engineering/Cell Biology

Location
Trondheim, Norway
Posted
18 Jun 2018
End of advertisement period
20 Aug 2018
Ref
154236
Contract Type
Temporary
Hours
Full Time

A PhD position is available at the Department of Clinical and Molecular Medicine. The position is financed by Norwegian Research Council via the Biotech 2021 initiative Digital Life Norway and the project “3DLife: Emulating life in 3D with digital and experimental tissue models”. The Centre for Digital Life Norway is an unprecedented collaborative effort by the three major universities in Norway and the Norwegian Research Council to create a cutting-edge virtual centre for computationally based biotechnology training, research and innovation, converging experimental life science with theoretical and engineering disciplines.

For more information, visit www.digitallifenorway.org.

The position has a duration of 3 years.

Description of the project and of the position

The PhD project is a part of the larger project “3DLife: Emulating life in 3D with digital and experimental tissue models”. This is a multidisciplinary project with the aim to develop novel strategies for microtissue engineering in 3D, to provide model systems of organ function and bridge the gap to in vivo conditions. To understand how the microenvironment affects cells we synthesize novel and tunable extracellular scaffold materials, and develop tools for high-throughput screening (HTS) of 3D cell cultures to assess genetic expression patterns in response to defined scaffold properties.

We will use a digital approach to process the vast data output from HTS analyses and provide a systems-level understanding of material-cell interactions. By applying a computational model, we aim to predict the requirements of organotypic cells to their microenvironment and tailor materials for improved in vivo-like tissue and organ models for research and clinical applications beyond the state of the art.

The available PhD project is focused on the investigation on sustained fibroblast function controlled by best available 3D scaffolds developed earlier in the project. This will involve evaluation of cell behavior, morphotype and phenotype based on cell health, cell surface markers, interactions with the scaffold, and cell networking that will serve as input and validation into the digital models of 3D microtissue function. The position will also establish multicell-type co-culture methods and microscopic monitoring of growth balances, cellular self-organization and longevity of co-cultures in optimized scaffolds. Finally, the project will evaluate the long-term sustainability of the best constructs in perfused bioreactors.

The project is expected to gain basic knowledge in physical and biological factors contributing to fibroblast phenotype.

The period of employment for the position as a PhD Research Fellow is 3 years. The position has the objective of qualifying for higher academic positions. Admission to a doctoral degree program is a requirement for employment as a PhD candidate. For regulations concerning the PhD-degree at NTNU, please see: http://www.ntnu.no/studieavd/dok/PhD_regulations.pdf

Requirements of the applicant:

  • A master’s degree or an equivalent education within molecular medicine, cell biology, stem cell biology, cellular biotechnology, biophysics, bionanotechnology or similar.  
  • A strong academic record with a weighted average grade of master’s or equivalent education with a grade of B or higher, in accordance with NTNU’s grading system.
  • Proficiency in oral and written English.

Emphasis will also be placed on:

  • Experience in working with live mammalian cells.
  • Experience with cellular imaging is a clear advantage.
  • Prior experiences in organ-on-chip, microfluidics or 3D cell cultures is an advantage.
  • Excellent communication skills, both oral and written.
  • Ability to work independently and in a team.

Terms of employment

The position offers work with challenging and varied tasks in a versatile and pleasant environment that is characterized by active, committed and skilled employees.

A good work environment is characterized by diversity. We encourage qualified candidates to apply, regardless of their gender, functional capacity or cultural background. If necessary, we will adapt the workplace for people with disabilities. Increasing the number of women in academic positions is an important priority for the Norwegian University of Science and Technology, and we especially encourage women to apply.

More information regarding moving to Trondheim, Norway and working at NTNU.

Depending on qualifications and academic background, PhD Candidates (in code 1017) at the Faculty of Medicine and Health Sciences will be remunerated at a minimum of NOK 436 500 per year before tax. Normal wage level is NOK 436 500 - 499 200 of which 2% is deducted for the Norwegian Public Service Pension Fund.

The appointment will be made in accordance with current regulations and supplementary rules with guidelines for employment as PhD Candidate appointments at universities and university colleges.

How to apply:

Applicants are asked to apply via this page. The application should contain the following attachments:

  • Applicants’ CV (including list of publications, relevant former positions and references) and copy of relevant transcripts and diplomas.
  • Short statement on the applicant’s personal qualifications and motivation for the position.
  • Short statement from a former supervisor/tutor/teacher.
  • Contact information for two references.
  • Other relevant attachments.

Candidates from universities outside Norway are kindly requested to send a Diploma Supplement or a similar document, which describes in detail the study and grade system and the rights for further studies associated with the obtained degree: http://ec.europa.eu/education/tools/diploma-supplement_en.htm

Deadline for applications: 20.08.2018.

Chosen applicants will be invited to undergo an interview.

For further information about the position, please contact Dr. Øyvind Halaas, telephone: 97790870, e-mail: oyvind.halaas@ntnu-no

For information concerning the application process, please contact the HR Executive Officer Elisabeth Myrvang: elisabeth.myrvang@ntnu.no

Please note that under the Norwegian Civil Service Act, information about applicants may be made public even though the applicant has requested not to be included on the list of applicants.

About this job

  • Deadline Monday, August 20, 2018
  • Employer NTNU - Norges teknisk-naturvitenskapelige universitet
  • Website
  • Municipality Trondheim
  • Jobbnorge ID 154236
  • Scope Fulltime
  • Duration Temporary

About applications

  • Applications on this job are registered in an electronic form on jobbnorge.no
  • You must complete: Standard CV
  • Please refer to where you first saw this job advertised!