TECHNISCHE UNIVERSITAT DRESDEN (TU DRESDEN)

Research Associate / PhD Student / Postdoc - Molecular Bioengineering

Location
Dresden (DE)
Posted
22 Mar 2018
End of advertisement period
02 May 2018
Contract Type
Fixed Term
Hours
Full Time

At the Center for Molecular Bioengineering (B CUBE), an Institute of the Center for Molecular and Cellular Bioengineering (CMCB), in the Chair of Biomimetic Materials (Prof. Nils Kröger and Dr. Nicole Poulsen, http://www.bcube-dresden.de/research-groups/kroeger/home/) a position as 

Research Associate / PhD Student / Postdoc

is available immediately. Subject to personal qualification employees are remunerated according to salary group E 13 TV-L 65% (PhD student) or E 13 TV-L (Postdoc). The position is initially limited for 3 years (PhD Student) or 2 years (Postdoc) as part of the DFG project ‘The Molecular Basis of Diatom Adhesion and Motility’ with the possibility of extension. The period of employment is governed by the Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG). The position offers the chance to obtain further academic qualification (e.g. PhD / habilitation thesis).

Tasks: The successful applicant will work on ‘The Molecular Basis of Diatom Adhesion and Motility’. Diatoms are a large group of unicellular eukaryotic algae that possess intricately nanopatterned silica cell walls. They are responsible for about 20% of global biological carbon fixation, form a substantial basis of the marine food web, and are major contributors to climate change processes. Benthic, pennate diatoms are well known for their adhesion strength to natural and man-made surfaces forming dense brown biofilms on submerged surfaces (biofouling). The annual cost of ship biofouling exceeds $150 billion, and thus understanding the molecular mechanism of diatom adhesion will inform the development of novel ship hull designs with anti-biofouling properties. At the same time, insight into the structure-function relationship in diatom adhesives will pave the way for designing biomimetic water compatible glues for technological and medical applications. Many adhesive diatoms have the ability for rapid gliding on underwater surfaces that is fueled by an as yet uncharacterized intracellular actin-myosin complex. Diatom motility is unrivalled among actin-based motility systems as it is extremely fast (25 µm/s) and bi-directional. Investigating the molecular basis of this process will therefore lay the groundwork for discovering new chemo-mechanical principles in actin-myosin dependent cell motility. The main aims of the research projects are identification and functional characterization of proteins of the machinery that generates the force for diatom motility. The project will utilize a variety of techniques including biochemical, molecular genetic, and molecular cell biological approaches.

Requirements: university degree (MSc), and - if applicable - PhD degree, in biochemistry, biological chemistry, molecular biotechnology, or related fields; strong research experience in protein biochemistry; excellent communication skills in English as this is the language at the research centre. 

The B CUBE http://www.bcube-dresden.de and its partner institutions, the Biotechnology Centre (BIOTEC) and the Center for Regenerative Therapies Dresden (CRTD), are equipped with state-of-the-art facilities for Molecular Bioscience research http://biotp.tudresden.de/biotechnology-platform/. They are part of a rich and collaborative environment that includes the School of Science, the Faculty of Medicine, the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), and the Leibniz Institute of Polymer Research Dresden (IPF). 

Applications from women are particularly welcome. The same applies to people with disabilities. Complete applications (letter of motivation, CV, list of publications, and certificates of qualifications) should be sent via the SecureMail Portal of the TU Dresden https://securemail.tu-dresden.de in a single pdf-file to nora.froehlich@tu-dresden.de or via post to TU Dresden, B CUBE, Herrn Prof. Nils Kröger, Arnoldstr. 18, 01307 Dresden until 02.05.2018 (stamped arrival date applies). Please submit copies only, as your application will not be returned to you.