Research Associate - Institute of Pharmacy and Biomedical Sciences
Department: Strathclyde Institute of Pharmacy and Biomedical Sciences (www.strath.ac.uk/sipbs/)
Faculty: Faculty of Science (www.strath.ac.uk/science/)
Staff Category Research
Reports To Prof John McCarron & Dr Calum Wilson
Salary Range: £31,604 - £34,520 per annum (restricted by grant funding)
FTE: 1 (35 hours/week)
Reference No 96164
Contract Type: Fixed Term (24 months)
Closing Date Sunday, 3 December 2017
Applications are invited for a post-doctoral position funded by the British Heart Foundation to study endothelial Ca2+ signalling in small arteries in hypertension. The successful applicant will join a well-funded and equipped lab carrying out endothelial imaging using novel imaging methods and analyses to address fundamental problems in vascular physiology. The endothelium controls virtually every cardiovascular function and changes in the behaviour of the cells underlies almost all cardiovascular disease. The overall objective of the project is to visualise and quantify the signalling patterns that occur in endothelial cells and the changes associated disease.
Different endothelial cells sense different stimuli and those cells sensitive to particular stimuli are clustered in close groupings. While different cells sense different stimuli, cells communicate so that when multiple stimuli arrive simultaneously each signal input modifies the response of the other cells and clusters even if these are not specifically sensitive to the stimuli. We are interested now in understanding precisely how the cells and clusters communicate with each other and what goes wrong with the communication in hypertension. The overall objective is to visualise and quantify the signalling patterns in that control all vascular function and their subsequent breakdown in disease, specifically in hypertension. The successful applicant will apply large-scale and high-resolution imaging and custom-designed analysis approaches to understand how the endothelium coordinates vascular function in intact blood vessels. We welcome applicants from a wide range of backgrounds although some experience in imaging or vascular biology would be an advantage.
The successful applicant will apply large-scale and high-resolution imaging and custom-designed analysis approaches to understand how the endothelium coordinates vascular function in intact blood vessels.. Where required, the successful applicant will receive training in imaging, image analysis, electrophysiology and myography (Faseb J. 30, 2000-2013, doi:doi:10.1096/fj.201500135 (2016); J Physiol 594, 4283-4295, doi:10.1113/JP271942 (2016); J. Physiol. doi: 10.1113/JP272927 (2016) Nature Scientific Reports 30, 2000-2013, doi:10.1038/srep16875 (2015); J Physiol 593, 5231–5253; J Physiol 594, 7267–7307, doi:doi:10.1113/JP272927 (2016) Trends Pharmacol Sci 38, 322-338, doi:10.1016/j.tips.2017.01.008 (2017)).
You will have, or soon expect to have, a PhD or similar experience in one or more areas covering of endothelial or vascular biology or optical imaging. An interest in interdisciplinary research, involving and willingness to communicate across traditional scientific boundaries is vital as these posts involve collaboration with cross disciplinary partners beyond the core team.
Further information on the application process and working at Strathclyde can be found on our website. Informal enquiries about the post can be directed to Prof John McCarron, 0141 548 4119; firstname.lastname@example.org.
Formal interviews for this post will be held on Friday, 15 December 2017.
Equality and Diversity
We value diversity and welcome applications from all sections of the community. The University currently holds a Bronze Athena SWAN award, recognising our commitment to advancing women's careers in science, technology, engineering, maths and medicine (STEMM) employment in academia.