Research Associate in Cell Biological Mechanisms

Bristol , City of Bristol (GB)
24 Oct 2017
End of advertisement period
19 Nov 2017
Contract Type
Fixed Term
Full Time

Research Associate

Job number  ACAD102945
Division/School  School of Cellular and Molecular Medicine
Contract type  Fixed term contract staff
Working pattern  Full time
Salary   £32,548 - £36,613 per annum
Closing date for applications   19-Nov-2017
The cellular mechanisms of novel reagents to enhance the anti-tumour immune response
We are looking for a talented, highly motivated postdoctoral Research Associate to investigate the cell biological mechanisms of action of novel immunooncologics in confidential collaboration with a large, research-oriented pharmaceutical company.
While the immune system effectively recognises tumours, the central anti-tumour immune effectors, cytotoxic T cells, are commonly suppressed within the tumour microenvironment. Reagents to overcome such suppression show great therapeutic promise in enhancing the anti-tumour immune response and are under development in many pharmaceutical companies. To kill a tumour cell, a cytotoxic T cell has to bind and polarise towards it. The investigation of T cell polarisation and its regulation with live cell imaging approaches under physiologically relevant conditions is a key expertise of our laboratory and we will apply it here to elucidate the cellular mechanism of action of exciting new reagents to enhance the anti-tumour immune response. This is an opportunity to perform cutting edge research in immunooncology at the interface between academia and the pharmaceutical industry.
The project is funded for 12 months and will be held within the School of Cellular and Molecular Medicine. With this advertised position, we are looking for a postdoctoral Research Associate for the six-month period covering the second half of the project that runs from January through June 2018. Upon generation of meaningful outcomes it is likely that the post will be extended.
The position is open to candidates who have or are soon to obtain a Ph.D in biomedical or related sciences. A proven ability to creatively investigate complex systems in the wider range of molecular biology is essential.
For informal enquiries, please contact Christoph Wuelfing, T: +44 (0) 117 33 12364; E:
The closing date for applications is midnight on Sunday 19 November 2017
Interviews will be held late November 2017 / early December 2017
The University is committed to creating and sustaining a fully inclusive culture.  We welcome applicants from all backgrounds and communities.

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