UNIVERSITY OF BRISTOL

Research Associate / Senior Research Associate in Applied Genetic Epidemiology

2 days left

Location
Bristol , City of Bristol (GB)
Posted
23 Oct 2017
End of advertisement period
19 Nov 2017
Contract Type
Permanent
Hours
Full Time

Research Associate / Senior Research Associate in Applied Genetic Epidemiology

Job number  ACAD102899
Division/School   Academic Faculties
Contract type  Open ended contract staff
Working pattern   Full time
Salary   £36,613 - £41,212 per annum
Closing date for applications    19-Nov-2017
 
An opportunity has arisen for a talented epidemiologist with a keen interest in biomedical research, experience of working with genetic data, and a systematic and thorough approach to their work.
 
Cancer Research UK (CRUK) have funded a major 5 year programme of interdisciplinary research to investigate the molecular epidemiology of cancer. In this programme we aim to reduce the burden of cancer by identifying risk factors, mechanisms and predictive biomarkers that will inform diagnosis and treatment of several different cancers. The programme integrates multiple high-throughput ‘omics’ platforms within large-scale epidemiological studies and applies innovative causal analysis methods to robustly discriminate between exposures that are causally associated with cancer risk and progression, and hence are possible targets for intervention, from non-causal biomarkers with potential predictive utility.
 
The successful applicant will work on a project within the causal analysis (‘Mendelian randomization’) work package (WP1) of the CRUK Programme to determine whether folate and other metabolites in the one-carbon pathway are causal risk factors for cancer using Mendelian randomization. The plan is to initially investigate all cancers in a large population based cohort (UK-Biobank), and then look at specific cancer sites using genome wide study data from large cancer collaboratives. This project will involve: identifying single nucleotide polymorphisms associated with folate and other B-vitamins from genome wide association studies; applying to access genome wide association study (GWAS) data from international collaborations on cancer; collating and harmonizing summary association data from those genome wide association studies; carrying out Mendelian randomization analyses; and performing systematic reviews across studies.
 
This position would be particularly suitable for individuals with an interest in applying for externally funded research fellowships in cancer epidemiology, with a focus on genomics.
 
Informal enquiries can be made to Dr Sarah Lewis; S.J.lewis@bristol.ac.uk Tel: (0117) 33 13316
 
Please note we are also advertising the role of Research Associate / Senior Research Associate in Applied Genetic Epidemiology. Vacancy number ACAD102900.
 
It is expected that interviews will take place on Tuesday 5 December 2017
 
The University is committed to creating and sustaining a fully inclusive culture.  We welcome applicants from all backgrounds and communities.