UNIVERSITY OF BRISTOL

Research Associate 

1 day left

Location
Bristol , City of Bristol (GB)
Salary
£32,548 - £36,613 per annum
Posted
14 Sep 2017
End of advertisement period
25 Sep 2017
Contract Type
Permanent
Hours
Full Time

Research Associate 

Job number  ACAD102860 
Division/School   School of Biochemistry 
Contract type   Open ended contract staff 
Working pattern   Full time 
Salary  £32,548 - £36,613 per annum 
Closing date for applications  25-Sep-2017 
Location: Bristol, UK
 
A Postdoctoral Research Associate position in electron cryo-microscopy is available in the research team led by Prof Christiane Berger-Schaffitzel at the University of Bristol. The project is part of a dynamic, interdisciplinary collaboration with the research teams of Prof Ernest Laue at the University of Cambridge and Prof Imre Berger at the University of Bristol.
 
The research centres on understanding the assembly, structure and function of nuclear remodelling and deacetylase (NuRD) complexes, which play a key role in the early stages of differentiation of embryonic stem cells. We take a multi-disciplinary approach that combines electron cryo-microscopy, mass-spectrometry, X-ray crystallography, single molecule techniques, single-cell genomics methods and functional studies in mouse ES cells. For recent publications, please see: Zhang et al., Journal of Molecular Biology, 2016, 428(14): 2931-42; Stevens et al., Nature, 2017, 544(7648): 59-64.
 
A central component of our research is the high-resolution structural and biochemical analysis of the interaction of NuRD complexes with nucleosomes by electron cryo-microscopy. You will undertake structural studies using cryo-EM and would be supported by the excellent environment and research facilities at the Universities of Bristol and Cambridge. It is envisaged that you would work at both locations, but be based primarily in Bristol.
 
Applicants should have a PhD in structural biology (or be due to complete a PhD within the next few months). Expertise in electron cryo-microscopy and image processing would be highly desirable, but experience with high-quality sample purification, protein characterisation and sample optimization, or protein production in insect cells would also be a plus.
 
The post is for 3 years initially with a possibility for extension. We are seeking to fill the post as soon as possible.
 
The Research Associate will benefit from the cutting-edge Bristol Biosuite for structural biology and the Synthetic Biology centre (BrisSynbio, www.bristol.ac.uk/brissynbio/), our new state-of-the-art Cryo-EM facility (Talos Arctica, with Energy Filter and DED), and access to Cryo-EM facilities and expertise at the University of Cambridge (Talos Arctica and Titan Krios).
 
For informal enquiries please contact: Professor Christiane Schaffitzel, +44 117 39 41869, christiane.berger-schaffitzel@bristol.ac.uk or Professor Imre Berger, +44 117 39 41857
 
The closing date for applications is midnight on Monday 25 September 2017.
 
The University is committed to creating and sustaining a fully inclusive culture.  We welcome applicants from all backgrounds and communities.