Fellow / Senior Fellow in Genome Sciences
The John Curtin School of Medical Research
Salary: $113,929 - $145,576 pa plus 17% employer superannuation
Term: Fixed Term: 7 years
The Department of Genome Sciences at The John Curtin School of Medical Research is currently expanding and we are seeking applications from highly motivated, internationally recognised scientists to establish and lead an independent research group related to the understanding of how genome is organized and expressed. The research-focused position will provide funding for seven (7) years that includes a salary and start-up package. Applicants will be expected to have an exceptional international research profile in any aspect related to genome function and/or gene expression demonstrated by high impact publications and the ability to attract competitive funding.
Department of Genome Sciences
Led by Professor David Tremethick, the overall aim of the Genome Biology Program is to understand the connection between genomes and phenotypes, and how this relationship is regulated in response to environmental and intrinsic signals crucial for cell development, survival and homeostasis. This is being achieved by combining experimental and computational approaches. Understanding this connection will uncover the aetiology of many diseases that involve individual genome differences and genome instability, which will have a direct impact on the new field of genomic medicine.
Using integrative genomic, genetic and biochemical approaches, our specific aims are:
- To determine how the expression of genomic information is both regulated and integrated to create complex networks needed to direct biological processes including development and disease. We are investigating how the flow of information from the genome is regulated by its organisation into the epigenome. In particular, we are integrating the role of the epigenome with key signalling and transcription molecules and elucidating the regulatory architecture of gene expression. The development of new statistical models and approaches for genome-wide analyses are critical to achieve this aim.
- Most genomic regions can be actively transcribed leading to a myriad of distinct RNA molecules, some coding for proteins but most are likely to have diverse regulatory functions. We are decoding the principles of this RNA-level regulation, with an emphasis on the dynamic and highly combinatorial interactions of RNA with proteins to form functional ribonucleoprotein particles. Proteomic and transcriptomic measurements and their computational analysis are key to these activities.
- To uncover the various mechanisms of transcriptional and post-transcriptional regulation mediated by chromatin, using model organisms, different types of cellular differentiation systems and in vitro transcription–chromatin approaches.
If you have the high-level experience and qualifications necessary to succeed and are keen to join our Department we would welcome your application. The Australian National University is an equal opportunities employer, encouraging applications from women and applicants from diverse backgrounds.
Appointments will be made at the relevant level according to skills and experience of the candidates.
The Australian National University provides attractive benefits and excellent support to maintain a healthy work/life balance and offers generous remuneration benefits, including four weeks paid vacation per year, assistance with relocation expenses and 17% employer contribution to superannuation. This also includes generous parental leave, the possibility of flexible and part time working arrangements, a parental and aged care support program, dual career hire programs, ANU school holiday programs, and childcare facilities on campus.
For more information, please visit the University’s job vacancies website, Ref: 493937, or contact Professor Simon Foote, School Director, JCSMR E: Simon.Foote@anu.edu.au, or Professor David Tremethick, Head of Department, E: David.Tremethick@anu.edu.au or visit the department’s website.