UMEA UNIVERSITY

Postdoctoral Research Position in Bacterial Physiology and Pathogenesis

Location
Umeå (SE)
Posted
17 Nov 2016
End of advertisement period
05 Jan 2017
Academic Discipline
Life sciences, Biological Sciences
Contract Type
Temporary
Hours
Full Time

Postdoctoral Research Position in Bacterial Physiology and Pathogenesis

Department of Molecular Biology

We are looking for a postdoc in cellular and molecular biology within the project “Controlling virulence in Yersinia pseudotuberculosis through accumulation of phosphorylated CpxR” funded by VR. The position is full time for two years and is placed at the Department of Molecular Biology, Umeå University, Sweden. The deadline for application is 5th of January, 2016 and the position is expected to start 1st of April 2017 or as otherwise agreed.

Project description

The research project will contribute to an ongoing analysis of the CpxA-CpxR two-component regulatory pathway in the bacterium Yersinia pseudotuberculosis. This analysis has so far demonstrated how the Cpx signalling pathway functions in sensing noxious stress to maintain envelope integrity while repressing virulence gene expression; processes crucial to Yersinia survivability in extreme environments. Hence, of significance to the project’s progression would be studies that benefit understanding of CpxR~P as a transcription factor in controlling Yersinia pathogenicity and environmental survival, and studies that investigate the Cpx pathway as a possible target of inhibitory chemicals with anti-bacterial chemotherapeutic applications.

Important criteria for eligibility are

You have a PhD degree or a foreign degree that is deemed equivalent to a PhD in molecular microbiology or equivalent subject with an emphasis on the controlled regulation of gene expression. To be eligible you should have completed your PhD degree a maximum of three years before the end of the application period, unless special circumstances exist. Proficiency in experimental methodology working under Biosafety level 2 restrictions to measure patterns of expression for specific genes (eg.: gene fusions, qRT-PCR, northern blotting etc.) and to measure DNA-protein interactions (eg.: EMSA, footprinting assays, ChIP assays etc.) is required. You have a high proficiency in both written and spoken English. You also have an ability to communicate research data in peer-reviewed international scientific publications and at international research workshops or conferences.

You are highly motivated, have strong curiosity and focus, and have an ability to work independently and interact in a collaborative manner with other team members to accomplish organizational goals.

We also see that you have an ability to provide ideas to improve research efficiency within the group.

Other qualifications of merit

Knowledge of high-throughput screening assays as well as knowledge of bacterial two-component signalling and phosphotransfer reactions between proteins is strong merits. Experience using eukaryotic model systems to study bacterial pathogenesis is also a merit.

How to apply

You apply through our recruitment system. Log into the system and apply via the button at the bottom of the webpage. The application should include:

  • A personal cover letter explaining why you are interested in the position and how you can contribute to the project (no more than one A4 page).
  • A curriculum vitae, including a list of university courses and certified copies of PhD certificate and transcripts with grades.
  • Names, with contact details and e-mail addresses of two to three academic references.
  • Your publication list

  • Other relevant documentation you wish to include in support of your application.

Deadline

2017-01-05

More about us

More information about the department http://www.molbiol.umu.se/english

Type of employment

Temporary position longer than 6 months

Extent of employment

100%

Salary

Monthly salary

Contact

Matthew Francis, professor
Tel: matthew.francis@umu.se

First day of employment

1st of april or as otherwise agreed