Research Associate in Medical Science
5 days left
- Full Time
- One of the Asia-Pacific’s leading research intensive Universities
- Strong regional and global engagement
- Cutting edge facilities and equipment
At UNSW, we pride ourselves on being a workplace where the best people come to do their best work.
About the role
- $70,381 – $93,840 plus (9.5% superannuation and leave loading)
- Fixed term to 31 December 2017
- Full-time (35 hours per week)
The Research Associate will be responsible for a project which seeks to gain a better understanding of how frequent encounters of tumour cells in vivo leads to inactivation of CD8+ cytotoxic T lymphocytes (CTLs). To do so, the Research Associate will inoculate mice with tumour cells that express a tumour-specific model antigen followed by adoptive transfer of antigen-specific CTLs and isolation of functional and dysfunctional T cells. The signalling efficiency of these T cells will be examined ex vivo, using recently established single molecule localization microscopy (SMLM) approach and analysis (Pageon et al, PNAS 2016). The research will test the hypothesis that the spatial organisation of the TCR contributes to CTL inactivation by reducing signalling efficiency and that spatially controlled antigen presentation could potentially rescue inactive CTLs and improve tumour cell killing.
To be successful in this role you will have:
- A PhD in immunology, cancer biology, cell biology, (bio)physics, (bio)chemistry, or related science;
- Demonstrated experience in immunology and/or cancer biology using mouse models;
- Demonstrated experience advanced fluorescence microscopy and analysis, preferable single molecule imaging;
- Demonstrated experience in cellular and molecular immunology and/or cancer immunotherapy and experience in molecular biology and cell biology.
You should systematically address the selection criteria in your application.
Scientia Professor Katharina Gaus MPhil PhD (Cantab)
T: (61 2) 9385 1377
Applications close: 3 January 2017