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GMP Technician

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
£32,979 - £34,605 per annum, including London Weighting Allowance
Closing date
7 Jul 2024

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Job Details

About us

The King’s College London Gene Therapy Vector Facility (GTVF) provides comprehensive GMP-grade viral vector manufacturing services. This includes Lentiviral Vector (LV), Retroviral Vector (RV) and Adeno-Associated Viral Vector (AAV) production for early-phase clinical trials, alongside substantial programmes in process innovation, knowledge transfer and training to address critical skills shortages.

​In partnership with the Network of Innovation Hubs, our vision is to ensure that the UK capitalises on its outstanding academic medical research to deliver novel gene therapies to patients, providing transformative treatments for currently intractable conditions, and generating a vibrant economic landscape.

​The GTVF is run by a large, industry-leading team of >50 people who have extensive experience in delivering end-to-end viral vector manufacture for both academic and commercial clients, with a focus on early-stage clinical trials.​

About the role

The Cell and Gene Therapy, King's (CGT-K) group manufactures a variety of Advanced Therapy Investigational Medicinal Products (ATIMPs) and starting materials, in state-of-the-art Good Manufacturing Practice (GMP) facilities for treatment of cancer and rare diseases. This post supports the translation of cutting-edge medical research into clinical application. The position is based in a team with an excellent track record in both basic and translational research.

​The GMP Technician will work as part of the Technical and Quality Team to provide technical support to CGT-K ATIMP manufacturing activities and ensure the activities comply with the requirements of the Pharmaceutical Quality System (PQS).

​Tasks undertaken will include but not be limited to:

  • Carrying out routine environment monitoring of the GMP manufacturing suites . ​Performing weekly checks of the facilities (cleanrooms and ancillary areas) to ensure that they are fit for purpose, clean and tidy and stocked with routine consumables.  
  • ​Conduct regular stock checks and assist in the maintenance of the stock inventory. ​
  • Carry out day to day materials management activities including receipt of materials, QC approval against defined specifications. ​
  • Assist in the routine cleaning of the manufacturing facilities. ​Assist in the shipment of samples to testing sites. ​Handling and acknowledgement facility / equipment alarms. ​D 
  • Draft quality system documentation including but not limited to Standard Operating Procedures and Batch Manufacturing Records and deviations.
  • ​Participate in internal and external audits including regulatory audits.  
  • ​​​Assist in the routine weekly/ fortnightly and monthly cleaning of the Manufacturing suites, as required.
  • Assist in management of equipment servicing, calibration activities
  • ​Manage the shipping of routine QC samples to external testing sites, ensure temperature logs are received from the courier and reviewed for compliance with specification.

​​This is a full time post (35 hours per week), and you will be offered an indefinite contract.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

  1. Secondary Education to A level or equivalent
  2. Experience in maintaining databases or tracking spreadsheets 
  3. Experience in stock management and /or inventory systems
  4. ​Experience in liaising with suppliers or service providers 
  5. ​Hands-on experience of environmental monitoring in a GMP cleanroom setting
  6. Experience in cleaning/ decontamination of GMP cleanrooms/ controlled environments
  7. ​Basic knowledge of a formal quality system. ​Experience in working to SOPs or written formal instructions
  8. ​Excellent organisational skills with demonstrable ability to balance competing demands and priorities. Ability to work both in a team and independently. ​Excellent interpersonal and communication skills

Desirable criteria

  1. Working knowledge of QA/QC in relation to production of IMPs in particular Change Control, Document Control, Process Validation, Equipment Management CAPA, Quality Risk Management
  2. Experience of working in or maintaining a cleanroom environment

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further information

This post is subject to Disclosure and Barring Service.

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community. 

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

Interviews are due to be held on week of the 24th July 24

We are  not able to offer sponsorship for candidates who do not currently possess the right to work in the UK.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
GB

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