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Research Assistant OR Postdoctoral Research Associate in Radionuclide Physics

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
Grade 5 (£37,332 - £42,099) or Grade 6 (£43,205 - £50,585) per annum, including LWA
Closing date
15 Jul 2024

Job Details

About us

The successful candidate will work closely with Dr Terry, her team, and industrial collaborators at Perspective Therapeutics, as well as collaborate with other members of the Department of Imaging Chemistry and Biology and scientists and clinicians at external institutions and universities.

About the role

We are seeking a Research Assistant or Postdoctoral Research Associate to work on an exciting project to enhance therapeutic options for patients with neuroendocrine tumours. The person will carry out cellular and preclinical dosimetry using (and acquiring if so desired) data from radiochemical/biological studies to create, characterise, and test new molecular radionuclide therapies beyond beta particle-emitters both in vitro and in vivo in tumour and healthy cells and tissues. Approaches will be both as single therapies and in combination with chemotherapies. Radionuclide imaging studies alongside the above data will be used to inform dosimetry. This post will work closely with a postdoc with biological expertise already in place. 

Improvement of cancer treatment remains a priority as 28% of UK deaths are still attributable to cancer. Neuroendocrine tumours (NETs), whilst rare, are the exemplar cancer type investigated here as they are hard to treat. External beam radiotherapy and molecular radionuclide therapy in the form of 177Lu-DOTATATE have enhanced survival for some NET patients, but the long-term outlook for most patients with advanced NETs remains poor.

This work will

  1. directly influence future clinical trial design in neuroendocrine cancer patients undergoing injectable radioactive therapy as part of their treatment;
  2. provide evidence to convert radionuclide therapy from palliative to curative options in cancer;
  3. provide key building blocks with which to create other effective radionuclide therapies as well as impactful combination therapies.  

The work spans cellular and preclinical tumour and health organ dosimetry and can be easily carried out by somebody with Monte Carlo modelling skills and a good understanding of the basic radiation dosimetry principles. Optional experimental work spans molecular biology, in vitro cell studies and preclinical in vivo therapy and radionuclide SPECT and/or PET imaging studies, and radiobiology.

The team is committed to providing an inclusive and supportive environment for all. See https://www.radlab.uk/team and associated pages for more on who we are and what we do. 

This is a full time post (35 hours/pw), and you will be offered a fixed term contract until 17 September 2026.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

  1. BSc (2:1 or above) in Physics or other relevant field - (Grade 5)
  2. PhD awarded or near completion in radiobiology, computational modelling, medical physics or other relevant field (or pending results) - (Grade 6 only)
  3. Highly computer literate with coding expertise, e.g. MATLAB, Python
  4. Expertise in dosimetry programmes and/or Monte Carlo modelling, e.g. MIRD, OLINDA
  5. Skills in presenting scientific research in the form of papers, posters and oral presentations - (Grade 6 only)
  6. Development of statistical and computational dosimetric methods if relevant
  7. Expertise in analysing in vitro and in vivo data to derive dosimetric parameters
  8. The ability to take individual responsibility for planning and undertaking own work, according to clinical and scientific deadlines and a collaborative approach to scientific research and showcasing honesty and integrity

Desirable criteria

  1. Experience in radiobiology or computational modelling
  2. Experience applying radiation dosimetry principles
  3. Radiation training and knowledge of handling and safety of biological and radioactive materials
  4. Experience in calibration procedures
  5. Experience in small animal radionuclide imaging studies

 Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘ How we Recruit’ pages.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
GB

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