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Research Associate in Translating In-Silico Cardiac Electrophysiology Procedure Guidance System

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
£43,205 - £50,585 per annum, including London Weighting Allowance
Closing date
3 May 2025

Job Details

About us

The successful applicant will be located with the newly created Research Department of Digital Twins (North Wing of St Thomas’ Hospital), primarily supervised by Dr Martin Bishop. The post will benefit from the computational and clinical electrophysiological infrastructure provided by the School of Biomedical Engineering & Imaging Sciences and will be based at St Thomas’ Hospital.

This work will be performed in close collaboration with the clinical researchers at KCL and St Thomas’ Hospital, lead by Dr John Whitaker and Prof Aldo Rinaldi. The project is also in direct collaboration with Prof Gernot Plank (Medical University of Graz) and the cardiac software and solutions company NumeriCor working with Dr Aurel Neic.

About the role

Catheter ablation therapy involves ‘burning’ small areas of cardiac tissue in order to permanently disrupt the problematic electrical pathways driving potentially lethal arrhythmias. However, procedure times and complication rates are high, whilst success rates are punitively low (~50% success), largely due to the significant challenges clinicians face in identifying the ideal ‘target’ to ablate. Here, we aim to further develop, and clinically validate, a novel in-silico tool that uses patient imaging data to reconstruct personalised ‘digital twin’ cardiac models to provide pre-procedural ablation target guidance. This will provide essential confidence and data to guide a follow-up prospective randomised clinical trial.

In this project, funded by an internal MRC Impact Acceleration Award, we will use currently-collected patient imaging data to further develop computational pipelines to reconstruct personalised image-based computer models of a patient’s heart. Imaging data, from modalities such as Cardiac MRI and Cardiac CT will be combined in order to best represent the patient’s cardiac anatomy, as well as the underlying fibrosis and scar tissue which are responsible for driving the lethal ventricular arrhythmias to be treated.  These patient models will then be used within our novel in-silico approach (patent filed) to rapidly simulate patient arrhythmias in near-real time. A crucial aspect of this work will be the further adaptation of this computational approach in order to automatically account for the inherent uncertainty in the clinical data, for example by considering different representations of the scar or of the functional parameters that go into the model. Finally, clinical electrical data from the cath-lab during patient procedures, in the form of both ECG and invasive electro-anatomical mapping data, will then be used to validate the arrhythmia ‘circuits’ predicted by the model.

This is a full time post (35 Hours per week), and you will be offered a fixed term contract up to 1 year.

About you

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

  1. 1st or 2nd class hons degree in computer science, biomedical engineering, physics, mathematics or related subject  
  2. PhD qualified in computer science, biomedical engineering, physics, mathematics or related subject (or pending results)* 
  3. Good programming skills in Python, Matlab and/or C++ 
  4. Experience in computational biophysical modelling and simulation 
  5. Good writing and presentation skills 
  6. Desire to work in medical modelling in a clinical environment 
  7. Flexible approach to hours of work and duties 
  8. Able to work on own initiative and in a team, and communicate effectively with people from wide variety of disciplines and organisations

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Desirable criteria

  1. Knowledge of cardiac physiology 
  2. Knowledge of how to perform numerical simulations and analysis 
  3. Advanced knowledge of signal and image processing techniques 
  4. Experience in cardiac research

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the next page after you click “Apply Now”. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's. We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ‘How we Recruit’ pages.

We are able to offer sponsorship for candidates who do not currently possess the right to work in the UK.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
GB

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