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Process Development Scientist

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
£42,099 per annum, including London Weighting Allowance
Closing date
7 Mar 2024

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Job Details

Job description

The Process Development Scientist for the Gene Therapy Vector Facility (GTVF) is a new role within the Process Development function. The post holder will work closely with colleagues in Production, Quality Assurance, Quality Control, to ensure manufacturing processes are evaluated and optimised to allow efficient operation and delivery of products for client projects.

The successful candidate will be leading projects/ programme of work under the direction of the Head of Process Development. The post holder will be responsible for technical evaluation of client proposals, proposing targeted lab work to optimise processes prior to manufacture, supporting risk assessments, biological safety evaluation and identifying and implementing improvements in manufacturing and analytics and evaluating new technologies to improve manufacturing capabilities.

This post will be offered on an indefinite contract.

This is a full-time post.

This post is subject to Disclosure and Barring Service clearance.

Key responsibilities

Communication & Networking

  • Conveying and understanding communication of a highly complex or conceptual nature.
  • Clear and precise communication of experimental plans and results to internal and external stakeholders. Choosing an appropriate method of delivery and employing techniques to ensure understanding.
  • Initiating, building and leading internal and external networks and maintaining on-going relationships with customers, suppliers and external agencies.

Decision Making, Planning & Problem Solving

  • Be able to take independent decisions and contribute to collaborative decisions that have implications for their work and that of others.
  • Be able to manage own workload and resources and prioritise to achieve objectives.
  • Be responsible for planning and leading projects/ work streams ensuring effective resources are allocated.
  • Inputting into longer term planning.
  • Able to resolve problems which maybe complex and require application of initiative and creativity. Proposing various solutions and evaluating options may be required.

Service Delivery

  • Responsible for providing and assisting in setting the standard of service.
  • Interacting with internal and external stakeholders, interpreting requirements and supporting junior staff in delivery of service.

Analysis

  • Gathering and analysing data so it can be interpreted by others for inclusion in reports or other documents.

  • Identifying and selecting the most appropriate procedure/ technique to conduct analysis to aid decision making.

  • Assisting other teams and junior staff to acquire and interpret data.

  • Collating and analysing data to determine process performance, trending to identify issues.

Teamwork, Teaching & Development

  • Sharing specialist knowledge of a particular area/ aspect of work and act as subject matter expert.
  • Ensuring other team members are informed of new process developments, technologies and techniques and leading training as required.

Measures of success

  • Technical knowledge in process development.
  • High degree of compliance with regulations.
  • High level of teamwork.
  • Contribution to sustained growth of manufacturing activities through improved processes.

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

  1. B.Sc/ M.Sc/Ph.D degree in a relevant science, engineering or life science discipline.
  2. Experience working in commercial companies within GMP Pharma/Biotech/Contract Manufacturing organisation (CMO) sectors.
  3. Experience with a range of biopharmaceutical and cell-based processes and techniques including cell culture and purification techniques.
  4. Significant experience gained in Process Development in a number of processes used in viral vector manufacturing demonstrating optimisation of processes delivering improvements in yield, quality and manufacturability.
  5. Experience in development of biopharmaceutical processes, quality compliance, process development/qualification, control strategy.
  6. Contributing to safety and quality risk assessments.
  7. Experience of managing change through GMP change control system 8. Significant experience of technology transfer covering donor and receiving site activities.
  8. Excellent verbal and written communication skills.
  9. High level of work organization, self-motivation, drive for performance and improvement and flexibility in approach and attitude.
  10. Comfortable working independently and building professional networks.

Desirable criteria

  1. Understanding of and familiarity with regulatory guidance governing cell-based and biopharmaceutical development.
  2. Application of DoE to process development.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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