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Research Fellow (Mechanobiology Institute)

Closing date
5 Jan 2024

Job Description

The Mechanobiology Institute, National University of Singapore is a multi-disciplinary institute committed to developing new paradigms for biomedical research by focusing on the quantitative analysis of dynamic functional processes. Through quantitative biophysical approaches, we address major problems in biomedical sciences including pathogenesis (from bacterial to cancer), tissue regeneration and function.

We are seeking to recruit a Postdoctoral Fellow (Research Fellow) to join Asst. Prof. Andrew Holle’s Confinement Mechanobiology group (established in January 2021). 

The Confinement Mechanobiology group's broad objective is to use mechanobiology principles and recent observations on the nature of small, fluid-filled ‘cellular highways’ in the interstitial extracellular matrix (ECM) to identify, engineer, and leverage the role of confinement in cell biology. It is interested in leveraging new molecular biology tools, including RNA-Seq, CRISPR screens, ChIP-seq, and engineered tensions sensor probes to better understand the mechanical and genetic responses of the nucleus to self-induced cellular confinement, and then extend these findings to the cytoskeleton, focal adhesions, and extracellular matrix. The MBI and NUS provide state-of-the-art facilities dedicated to microfluidics, high-resolution imaging, and cell culture that will support the fellow in training, setup, and execution of the project, and the successful candidate will have the opportunity to work closely with talented and motivated research staff, interdisciplinary PIs, and clinician scientists. Applicants with unique proposals relating to confinement mechanobiology within the scope of the lab, especially in the areas of microfluidics, cellular engineering, or biomaterials development are encouraged to apply. 


Candidates should possess the following:

  • a PhD in bioengineering, biology, biomedical sciences, or similar fields
  • a strong background in mechanobiology, molecular biology techniques, microscopy, and image analysis
  • Prior knowledge of microfluidics would be advantageous, though not a prerequisite
  • Excellent communication skills and engage in collaborative research in a highly interdisciplinary environment. 

Salary and benefits are commensurable to educational qualifications and working experience of the candidates. 

We regret that only shortlisted candidates will be notified.

Applications should include: 1) a brief description of research interests and experience, and 2) a full CV, with the names and contacts (email addresses) of two to three references.

Scientific enquiries can be sent to Asst. Prof. Andrew Holle at

More Information

Location: Kent Ridge Campus
Organization: Mechanobiology Institute
Department : Research
Employee Referral Eligible: No
Job requisition ID : 20413

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