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Senior Development/Production/QC Radiochemist

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater)
Salary
£42,405 - £49,785 per annum, including London Weighting Allowance
Closing date
14 Dec 2023

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Job Details

Job description

To work as part of a team of radiochemists involved in either the production quality control or development of radiopharmaceuticals in accordance with GMP requirements to set production schedules.  

The duties also include the development of new tracers by performing practical validation work as directed by more senior radiochemists; to support GMP compliance by performing practical validation work and updating SOP’s as directed by more senior radiochemists; and to support the training of other staff members, performing routine tasks and administrative work and acting as the contact with the clinical team on occasions when the need arises or is assigned to.

This post will be offered on an indefinite contract.

This is a full-time post - 100% full time equivalent.

 

Key responsibilities

  • Undertake commissioning, validation, production and QC analysis of PET radiotracers in accordance with GMP procedures.
  • Undertake technology transfer of new processes or procedures in relation to new radiotracers
  • Development of new analytical methods, synthesis procedures or new radiochemistries to bring online radiotracers for clinical production
  • Carry out practical validation work for development or GMP compliance as directed by a senior radiochemist.
  • Perform routine tests, inspections and maintenance on laboratory equipment and infrastructure.
  • Ensure accurate records are maintained of all production, QC, tests, development inspections and maintenance work in accordance with SOP’s.
  • Participate in a production, QC and development rota system to cover 06.00 to 18.30 assigned by the Production, QC, Development and Operations manager.
  • Comply with local rules for working in a controlled area.
  • Follow strict aseptic techniques when working in the isolator hot-cell.
  • Communicating technical problems with equipment or processes to other members of the team, cyclotron engineers, clinician’s and to senior members of staff.
  • Updating/writing SOP’s, logs and records and investigational reports where and when necessary or as is delegated to ensure they are accurate.
  • Scheduling their own priorities to ensure that tasks allocated on a daily or weekly basis are completed as required.
  • Perform routine administrative tasks such as ordering and recording of materials as directed.
  • Be trained on and apply syntheses/analytical methods for newly introduced radiotracers for research and clinical GMP use.
  • Train other staff, researchers or students in production or QC processes as required.
  • Raise Quality Occurrences, Deviations, Change Controls, CAPAs as required.
  • In the occasional non-availability of senior QC or Production staff, act as the point of contact between the PET production/QC team and the clinical team as appropriate.
  • Will actively engage with staff training programmes and be competent to perform GMP processes as required.
  • Will actively engage with Production and Development staff training and be competent to operate the hot-cells, automated synthesis platforms and dispensing platforms.
  • Will actively engage with QC staff training programme and be competent to operate all of the QC equipment in the laboratory (including, automatic injection HPLC ((various detectors e.g.:  DAD, Conductivity, ECD) Gamma detector, GC, TLC etc., PTS) for GMP radiotracer productions.
  • Draft change controls for approval by QA.
  • Will raise Quality Reports and investigate quality exceptions including completing Root Cause Analyses and drafting Quality documents for approval by QA

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

 

Skills, knowledge, and experience

Essential criteria

  1. Degree in chemistry or pharmacy OR Broad vocational experience, acquired through a combination of job-related vocational training and considerable on the job experience, demonstrating development through involvement in a series of progressively more demanding relevant work/roles
  2. Knowledge of PET radiotracer synthesis and QC
  3. Radiochemistry/radiopharmacy laboratory experience
  4. Practical experience with the production and/or QC of PET Radiopharmaceuticals
  5. Practical experience of development PET radiotracer to preclinical
  6. Knowledge of and proven record in adhering to the principles of GLP and GMP
  7. Ability to amend documents eg SOPs
  8. Excellent verbal & written communication skills
  9. Excellent time keeping
  10. Flexible and able to work with a variety of people
  11. Flexible approach to hours & duties
  12. Ability to work on own initiative and in a multi-disciplinary team

Desirable criteria

  1. Knowledge of Ionising Radiation protection regulations
  2. Experience with automated synthesis equipment
  3. Experience of production to GMP standards

 

Further information

King’s recently published the Climate & Sustainability Action Plan (https://www.kcl.ac.uk/about/assets/pdf/strategy/kings-climatesustainability-action-plan-final.pdf), which outlines 13 key impact areas to guide the university’s approach and tangible steps to reach net-zero carbon by 2030. This plan was shaped by over 350 staff, students and alumni in the Climate Action Network (CAN) ( https://www.kcl.ac.uk/climate-sustainability/get-involved/kings-climate-action-network).

At the School of Biomedical Engineering & Imaging Sciences we take our role in minimising the negative and maximising the positive impacts seriously and seek to embed sustainability at every level within the department.

One way to get involved and support to embed sustainability is through participation in the Sustainability Champions programme ( https://www.kcl.ac.uk/climate-sustainability/get-involved/sustainability-opportunities-for-staff).

To find out more about sustainability at King’s including sustainable and responsible policies please visit:

https://www.kcl.ac.uk/climate-sustainability

https://www.kcl.ac.uk/climate-sustainability/operations-policies

This post is subject to Disclosure and Barring Service and Occupational Health clearance.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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