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Research Associate

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater) (GB)
Salary
£42,405 per annum, including London Weighting Allowance.
Closing date
4 Jan 2024

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Job Details

Job Description

Applications are invited for two postdoctoral research associate positions in Dr. Angika Basant’s group at the Randall Centre for Cell and Molecular Biophysics, King’s College London.

The Basant group, funded by a grant from the Wellcome Trust, seeks to understand how tyrosine phosphatases regulate cell signalling. This large family of enzymes has been highly understudied compared to its kinase counterpart. We investigate these phosphatases in the context of signalling to the actin cytoskeleton and in virus-infected cells.

Post 1 of 2: The researcher appointed to Post A will focus on candidate phosphatases that have been validated to regulate actin dynamics during infection with the poxvirus Vaccinia. How do these phosphatases function, what are their key interactors and how do they recognise substrates? The broader goal is to contextualise these findings in uninfected cells and, with the help of a collaborator, in other viral infections. For this role, experience in phosphatase biology, cell signalling or biochemistry is desirable but not mandatory.

Post 2 of 2: The researcher appointed to Post B will use quantitative microscopy techniques to elucidate how candidate phosphatases impact phosphotyrosine signalling dynamics and outputs. They will take advantage of, and further develop, a Vaccinia virus-based signalling platform, as well as cutting-edge molecule counting and optogenetics tools available in the lab. For this role, experience in phosphatase biology or cell signalling is desirable but not mandatory.

A PhD in a relevant discipline is required (or applicant to be near completion). A high-quality publication record and effective science communication skills are essential. International applicants are welcome.

Please reach out to Dr. Angika Basant (angika.basant@kcl.ac.uk) for informal discussions on either posts.

This post will be offered on a fixed-term contract until 30th April 2027.

This is a full-time post. We are looking for candidates to start no earlier than 1st May 2024.

Key responsibilities

  • Independently manage and execute specific aspects of the research project (including literature reviews, data collection and analysis, report writing) to an agreed timeline
  • Attend and present research findings at internal academic meetings and external professional conferences
  • Contribute to publications arising from this research
  • Facilitate collaboration and networking opportunities for the lab
  • Be committed to your personal career development goals and work collaboratively with your PI to achieve these
  • Communicate and collaborate effectively with other researchers working in the lab and with administrative teams for support
  • Assist in laboratory management and training of other lab members

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

Skills, knowledge, and experience

Essential criteria

  1. PhD in a relevant discipline (or close to PhD award)
  2. Strong track record in a key subject area such as cell signalling, cytoskeleton or similar
  3. Excellent experimental skills and strong ability to lead project design and management
  4. An enthusiasm for the research questions being addressed in the lab
  5. Strong communication skills both in writing and for oral presentation
  6. Collegiality and ability to work well in a research team
  7. Ability to work independently, take initiative, learn new skills and troubleshoot technical problems
  8. Good time management and organisational skills
  9. Scientific rigor and integrity
  10. Good practice in health and safety procedures
  11. Experience in microscopy (Post B only)

Desirable criteria

  1. Experience in supervision and teaching of other researchers
  2. Knowledge of phosphatase biology and/or phosphotyrosine signaling
  3.  Experience in biochemistry and/or proteomics (Post A only)

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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