Post-doctoral Research Fellow, School of Mechanical and Materials Engineering
Applications are invited for a temporary post of a UCD Post-doctoral Research Fellow Level 1 (Skin Bioengineering) within UCD School of Mechanical and Materials Engineering
The School of Mechanical and Materials Engineering at University College Dublin is looking to recruit 2 Postdoctoral Research Fellows Level 1 for 3-years each in Skin Bioengineering.
The Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) operates at the crossroads of engineering, chemistry, biology, medicine, entrepreneurship, humanities and social sciences, where education, research, innovation, social responsibility and clinical practice merge to improve human lives. REMODEL is a multidisciplinary and intersectoral hub that develops, derisks and commercialises transformative and disruptive end-user informed: A. Biomaterial- and cell- based therapeutic, reparative and regenerative products for healthcare. B. In vitro pathophysiology models for drug discovery. C. Cellular agriculture and aquaculture meat products for food security. D. Tools and technologies that enable effective and efficient ex vivo cell propagation for the cell culture sector.
Direct cell injections were introduced in regenerative medicine as a means to restore lost tissue function, following disease or injury. Unfortunately, soon it became apparent that the mode of administration neither protects nor localises the injected cells at the implantation site. To overcome these limitations, the concept of tissue engineered in vitro organogenesis has been pioneered that allows for the production of tissue-like assemblies in vitro. Although such approaches have demonstrated safety and efficacy in preclinical and clinical settings, only a handful of products have been commercialised. This limited technology transfer has been attributed, among others, to the prolonged in vitro culture required to develop a barely three-dimensional implantable device. Further, these prolonged ex vivo cultures are associated with phenotypic losses and very high manufacturing costs. This project will utilise recent advancements in engineering (e.g. nano- and micro- scaffold fabrication technologies) and cell culture technologies (e.g. media supplements, mechanical loading / oxygen tension bioreactors) to accelerate the development of clinically and commercially relevant three-dimensional advanced therapy medicinal products for skin bioengineering purposes. Extensive in vitro and in vivo analyses will be conducted in our state of the art facilities, housed at School of Mechanical and Materials Engineering; Charles Institute of Dermatology and Conway Institute of Biomolecular and Biomedical Research.
Salary: € 42,033 - € 48,427 per annum
Appointment on the above range will be dependent on qualifications and experience
Closing date: 17:00hrs (local Irish time) on 2nd of October 2023.
Applications must be submitted by the closing date and time specified. Any applications which are still in progress at the closing time of 17:00hrs (Local Irish Time) on the specified closing date will be cancelled automatically by the system. UCD are unable to accept late applications.
UCD do not require assistance from Recruitment Agencies. Any CV's submitted by Recruitment Agencies will be returned.
The PD1 position is intended for early stage researchers, either just after completion of a PhD or for someone entering a new area for the first time. If you have already completed your PD1 stage in UCD or will soon complete a PD1, or you are an external applicant whose total Postdoctoral experience, inclusive of the duration of the advertised post, would exceed 4 years, you should not apply and should refer to PD2 posts instead.
Prior to application, further information (including application procedure) should be obtained from the Work at UCD website: https://www.ucd.ie/workatucd/jobs/