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Skin Biomarker Research Fellow

Employer
KINGS COLLEGE LONDON
Location
London (Greater)
Salary
£49,737 - £58,421 per annum, including London Weighting Allowance
Closing date
25 Mar 2024

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Academic Discipline
Clinical, Pre-clinical & Health
Job Type
Professional Services
Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description

Underneath the skin, there are two superhighways of chemical information. One of these is the blood, which is sampled using a needle, and the chemical information taken from it is used to understand, diagnose and treat disease. The second, the interstitial fluid, contains more detectable chemical signals compared to the blood, but it is not currently used in clinical practice to diagnose or treat disease because it is difficult to sample.  

 

We are seeking a motivated research associate to help develop a new, needle-free prototype medical device. The innovative concept in the device is its use of hypobaric pressure to stretch the skin tissue in a manner that allows biomarker extraction. The initial development will occur using healthy adults as the test subjects and the device will pass through four developmental prototyping phases to optimise its ability to extract biomarkers. The types and levels of biomarkers extracted from the skin will be determined using mass spectrometry and electrochemical detection and these chemical signals will be compared to those in the blood. With the aid of a novel integrated mathematical model of skin stretching developed by the University of Surrey (project partners), the new medical device will be specifically adapted and scaled for use in a parallel clinical study conducted by a clinical team in babies.  

 

This exciting role requires a research associate capable of designing a range of different experiments, executing them efficiently and accurately interpreting their findings. Skills are needed in working with tissues, analytical techniques and biological samples. Experience of 3D printing and CAD design are highly desirable  but not essential. 

 

This post will be offered on an a fixed-term contract for 3 years 

This is a full-time post - 100% full time equivalent

 

Key responsibilities

•       Research: To conduct laboratory experiments, record results, interpret data and report the results. To use research skills to gather information from the scientific literature and use this information to construct and develop laboratory experiments.  

•       Administration: To manage the project budget, timelines and paperwork. To represent the Research Group as required at scientific meetings. To provide training and manage junior members of the research team. 

•       Communication & networking: Communicate internally and externally, using well- honed written and oral skills in a clear and accurate manner to a range of audiences. Have a high level of interpersonal communication. Interact with other members of the research team in an effective manner. 

 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post. 

Skills, knowledge, and experience 

Essential criteria 

1.       First degree in a relevant discipline 

2.       A sound (theoretical and practical) knowledge of an area of chemistry, pharmaceutical science, pharmaceutical analysis, medicine development medical analysis or medical device development  

3.       Evidence of strong laboratory skills 

4.       Good communication skills  

5.       Experience of scientific report writing and data presentation 

6.       Skills in handling biological samples 

7.       Skills in analytical assays 

 

Desirable criteria 

1.       Skills in product design and operating on computer-aided design CAD software e.g. Fusion 3D 

2.       Experience in additive manufacturing particular vat polymerization.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
GB

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