Job Description

The laboratory of A/Prof Victor Yu at the National University of Singapore (NUS) is currently recruiting a (Postdoctoral) Research Fellow. 

We are seeking for a motivated post-doctoral fellow to work on deciphering the roles of MOAP-1 in cellular senescence and ageing-associated disorders in liver. Long term goal of the project is to gain novel insights towards developing viable approaches for mitigating development and progression of these liver diseases.

Successful candidate will have the opportunity to work with a multidisciplinary team as well as collaborators in Singapore and overseas.

To facilitate a better understanding of the work being pursued in the laboratory, prospective applicants can refer to the following papers published by the lab: 

1. K.O. Tan et al., MAP-1 is a mitochondrial effector of Bax, (Track II), Proc. Natl. Acad. Sci. USA, 102: 14623-14688, 2005. (https://doi.org/10.1073/pnas.0503524102)
2. N.Y. Fu et al., Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria, (Track II), Proc. Natl. Acad. Sci. USA, 104: 10051-10056, 2007. (https://doi.org/10.1073/pnas.0700007104)
3. N.Y. Fu et al., Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism, Molecular Cell, 33: 15-29, 2009. (https://doi.org/10.1016/j.molcel.2008.11.025)
4. S.K. Sukumaran et al., A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to inhibit host cell apoptosis, Molecular Cell, 37: 768-783, 2010. (https://doi.org/10.1016/j.molcel.2010.02.015
5. C.T. Tan et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria, Cell Reports, 16:174-85, 2016.  (https://doi.org/10.1016/j.celrep.2016.05.068)
6. C.T. Tan et al., MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling, EMBO Reports, 22: e50854, 2021. (Featured as the cover story in Jan, 2021 issue: https://doi.org/10.15252/embr.202050854) 
7. H.C. Chang et al., The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore, Autophagy, 2021. (https://doi.org/10.1080/15548627.2021.1896157)

Responsibilities:

• Planning and execution of experiments using cell and mouse models 
• Guiding and working with junior staffs including students
• Participation in preparation of manuscript and research progress reports
• Uphold research integrity and ensure safety compliance 

Interested candidates please submit a detailed curriculum vitae, contact information for 3 references, and your earliest availability.

Please note that only shortlisted candidates will be notified.

Qualifications

Qualifications / Discipline:

• Ph.D. degree in Molecular Biology, Biochemistry, Cancer biology or other related fields is preferred.

Experience:

• Applicants with research experiences in mouse models and/or  some of the molecular cell biology techniques (e.g., primary cell preparations, CRISPR-Cas9 gene editing, confocal microscopy, FACS, histology, IHC, IF or protein-protein interaction) are preferred.

Skills:

• A team player and work well with colleagues
• Effective oral and written communication skills.
• Ability to work in a fast-paced environment.
• Other desirable attributes: self-motivated, organized, meticulous, efficient, and flexible.

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Kent Ridge Campus
Organization: Science
Department : Pharmacy
Job requisition ID : 18987