Research Fellow / Senior Research Fellow, Cancer Sciences

Cancer Sciences

Location:  Southampton General Hospital
Salary:   £34,314 to £48,423
Full Time Fixed Term (until 30/04/2025)
Closing Date:  Friday 31 March 2023
Interview Date:   To be confirmed
Reference:  2209623CM

About the Role

Applications are sought for a highly motivated Research Fellow / Senior Research Fellow to join a team investigating the role of cancer associated fibroblasts (CAF) in the tumour microenvironment . The project aims to identify novel targets that inhibit CAF function for future drug development. The research will be based in the School of Cancer Sciences, Faculty of Medicine, University of Southampton.

About You

Essential requirements include a PhD in cancer biology, immunology or related fields, appropriate publication records and a strong drive for research work. Significant research laboratory experience in cell culture and molecular biology techniques are essential and in vivo work would be desirable. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential. Willingness to work flexibly to achieve project demands will be needed.

About the School/Department/Institute/Project

This Boehringer Ingelheim-funded project will use a multidisciplinary approach to investigating CAF immunological functions and identifying novel strategies for targeting CAF as part of cancer therapy (eg. CJ Hanley et al., Nature Communications 2023; K Ford et al., Cancer Research 2020 [most cited Cancer Research paper 2020/21]; https://mydigitalpublication.com/publication/?i=741916;. The candidate will gain experience in fibroblast biology, including in vivo tumour models, functional tumour immunology and single cell sequencing. Active research themes in the lab include characterising CAF phenotypes in human tumours using single cell sequencing, studying CAF interactions with immune cells and identifying novel strategies for therapeutic targeting of CAF-containing cancers.   We enjoy close links with University Hospital Southampton and have a strong translational focus with excellent prospects for developing new therapies (eg. NCT05323656) and making a significant contribution to cancer treatment. The candidate will enjoy a vibrant multidisciplinary environment, take advantage of our ongoing collaborations with multiple industry collaborators and be provided with significant opportunities for excellent career development.

Benefits

We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum, and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements and campus facilities.

The post is based in the School of Cancer Sciences at Southampton General Hospital. It is full time, fixed term appointment for 24 months initially. The expected start date is from 1^st May 2023 onwards. The starting salary will depend on previous experience (appointed at Grade 4 or 5) in the range of £34,314 - £48,423 per annum.

Informal enquiries should be addressed to Gareth Thomas at g.thomas@soton.ac.uk +44 (0) 7845 361124

We are proactive in fostering a culture of inclusion, respect, and equality of opportunity. We select candidates based on merit and ability and aspire to thrive in the diversity of our workforce.  We welcome applications from all candidates with an interest in the role and those who are committed to helping us create an inclusive work environment. We encourage applications from candidates from Black, Asian, and Minority Ethnic communities, people who identify as LGBTQ+, and people with disabilities.  

Application Procedure 

The application deadline is midnight on the closing date stated above. If you need assistance, call Recruitment on  +44 (0) 23 8059 2750, or email recruitment@soton.ac.uk. Quote the advert reference on all correspondence.