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Research Associate - Cancer Immunology

Employer
KINGS COLLEGE LONDON
Location
London (Greater)
Salary
£40,386 - £44,931 including London Weighting Allowance
Closing date
23 Feb 2023

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Academic Discipline
Clinical, Pre-clinical & Health
Job Type
Research Related
Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description

As a research associate, the post holder will be required to provide high level intellectual and technical support to the experimental work being undertaken on project(s) under the supervision of Dr Sheeba Irshad.  Dr Sheeba Irshad is a medical oncologist with an interest in investigating the antigenic drivers of immune response in chemotherapy resistant breast cancers. Laboratory work will take place in Dr Irshad’s laboratory within the school of cancer and pharmaceutical sciences, Innovation Hub laboratories This post holder will work closely with colleagues working with the Breast Cancer Now Research Centre at the Institute of Cancer Research (ICR, Prof Andrew Tutt’s team) working alongside other wet lab, in-vivo, histopathology and bioinformatics teams.   

 

The candidate will be expected to take direct responsibility of specific research projects by providing original intellectual input, research project management and assist in preparation of manuscripts of the experimental work. The post holder will be proficient in cell culture, cell function assays, protein assays (e.g. ELISA, western blot) and multi-colour flow cytometry. The post holder will receive relevant supervision and training in specialized assays and will meet with his/her line manager on a regular basis to review results and plan experiments.  Equally, once established, the post holder should be able to work independently without the requirement of day to day supervision.

 

The post holder is encouraged to contribute to the design and execution of experiments under the supervision of a clinician scientist.  In addition, the post holder is expected to establish and maintain a collaborative working relationship both internally and externally. Where appropriate, the post holder should provide specialized laboratory skills training to junior staff.    The post will be based in the innovation hub at the Guy’s Hospital Campus, and will involve interaction with colleagues within the Breast Cancer Now Research Unit at the Kings College London and the Breast Cancer Now Research Centre at the Institute of Cancer Research, London.  

 

This post will be offered on an a fixed-term contract for 2 years  

This is a full-time post - 100% full time equivalent

 

Key responsibilities

•        To carry out research on defined, funded projects

•        To develop and refine experimental strategies

•        To ensure the validity and reliability of data at all times

•        To analyse and summarise research results and write reports and manuscripts

•        To support and advise other projects in the lab

•        To discuss experimental details, research projects and new articles with lab members

•        To be involved in weekly laboratory meetings

•        To attend research seminars and other meetings, both internal and external, as required

•        To present research results at meetings and conferences

•        To prepare and present findings of research activity to colleagues for review purposes

•        To contribute to, draft and submit papers to appropriate peer reviewed journals

•        To prepare progress reports on research for funding bodies as required

•        To contribute to the preparation and drafting of research bids and proposals

•        To contribute to the overall activities of the research team and department as required

 Skills, knowledge, and experience 

Essential criteria 

1.      PhD awarded in cancer immunology or similar  

2.      Experience in high dimensionalFLOW  and Mass cytometry (CyTOF)  

3.      Knowledge of in-vitro immunological assays including 3 dimensional tumour-immune co-cultures 

4.      Knowledge of relevant imaging platforms (e.g. multiphoton microscopy) and techniques  

5.      Indepth understanding of cancer immunology and immunotherapy 

6.      Interest in the field of translation cancer research 

7.      Experience in working in multidisciplinary teams  

8.      Experience of tissue culture 

9.      Strong problem solving abilities 

10.   An independent and innovative thinker 

 

Desirable criteria 

1.      Experience in the study and analysis of components of the immune system such as innate lymphoid cells, natural killer cells, monocyte/macrophage, and T regulatory cells 

2.      Basic knowledge of 3D imaging techniques and data analysis ®  

3.      Track record of publishing in cancer immunology, immunotherapy and tumour microenvironment as well as abstracts and presentations at national and international level.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

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