Postdoctoral Research Associate
- KINGS COLLEGE LONDON
- London (Greater)
- £40,386 per annum, including London Weighting Allowance
- 15 Jan 2023
- End of advertisement period
- 10 Feb 2023
- Academic Discipline
- Clinical, Pre-clinical & Health
- Job Type
- Research Related
- Contract Type
- Fixed Term
- Full Time
A Postdoctoral Research Associate position (PDRA) is available in the Trophoblast and Human Embryo Lab situated in the Centre for Gene Therapy and Regenerative Medicine at King’s College London. The post holder will support the research lead by Dr Norah Fogarty which seeks to understand the molecular processes that govern early placenta development in the human. Our goal is to identify signalling pathways active during trophectoderm and trophoblast differentiation and to determine their functional role in cell proliferation, gene expression and embryo development. This work will further our basic understanding of human biology which in turn could inform our understanding and treatment of infertility and placenta diseases such as miscarriage, preeclampsia, and intrauterine growth restriction.
In order to do so, we leverage
• Human preimplantation embryos, genetics and quantitative confocal imaging
• 2D and 3D in vitro culture model systems and live imaging to model development
The Fogarty lab offers: the opportunity to develop your own independent academic career; stable long-term funding and state-of-the-art resources to conduct cutting edge research in placenta development using human stem cell-based models and human embryos; family-friendly work culture; the possibility to work closely with clinicians and public engagement officers to drive a focussed programme of public outreach.
This full-time position (100% FTE) is available immediately for an initial period of 1 year with the possibility of extension.
The candidate should hold a recent PhD in a relevant discipline, or be awaiting viva examination, with at least one first author publication. The candidate should be familiar with embryonic stem cell culture, CRISPR/Cas9-mediated genome editing and scRNA-seq. Ideally we seek a person with experience in organoid culture and mammalian embryo handling. Experience with live imaging and light-sheet microscopy is advantageous.
Flexibility, conscientiousness, good interpersonal and organizational skills are required.
Excellent EU and international candidates are welcome to apply, and may be considered via the Global Talent visa scheme.
Please submit your complete application including a cover letter indicating the motivation to apply for this specific position, a CV including publication record, a description of previous research accomplishments (<1 page) and contact details of 2 approachable academic referees.
This post will be offered on a fixed term for 1 year, with the potential for extension.
This is a full-time post – 100% full time equivalent.- Click or tap here to enter text.
• Undertake original biomedical research as an integral member of a group working on embryo and placenta development, using human stem cells, organoids and embryos.
• Analyse signalling pathway activity and function using small molecule inhibitors, fluorescent reporters, high resolution imaging and spatial transcriptomics.
• Assist, supervise and train other members of the group, including students and other research staff in their application in related lab projects
• Manage project progress and set goals for achievement of project aims in collaboration with team leader including the execution of literature reviews, data collection and analysis, and report
• Prepare reports on results for verbal and multimedia presentations at regular lab meetings, departmental seminars, national and international meetings
• Prepare manuscripts for publication in peer review journals or book chapters
• Facilitate collaboration and networking, which engages and supports the activities of this research
• Communicate and collaborate with other members of the team and Centre
• Maintain up-to-date, accurate and comprehensive laboratory notes
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
1. PhD (awarded or near completion) in Biological Sciences or related discipline
2. Expertise in cell culture (human stem cells and/or organoids)
3. General web-lab skills including molecular biology techniques
4. Expertise in imaging acquisition (confocal, multiphoton microscopy)
5. Strong computing skills
6. Track record of publishing in the research area
7. Excellent communication (oral and written) skills
8. Self-motivated, with the ability to work under pressure & to meet deadlines
9. Working and designing experiments independently, excellent record keeping
10. Ability to supervise, work and integrate with others in the laboratory
11. Expertise in human embryology and development
12. Experience in high resolution live-imaging and light sheet microscopy
13. Experience in the use of imaging analysis software (Image J, Imaris, MATLAB, machine learning)