Research Fellow, CVMD / LH

15 Nov 2022
End of advertisement period
15 Dec 2022
Contract Type
Full Time

Job Description

The Ho lab is a world leader on small open-reading frame-encoded peptides (SEPs) and specialises in discovering new peptides required for mitochondrial function and metabolism. We previously discovered new mito-SEPs (mitochondrial sORF-encoded peptides) (Zhang et al., 2020, Nature Communications) and are working to assign molecular functions to them, with a special focus on the those involved in immune-metabolism. To this end, we aim to uncover new concepts in the metabolic regulation of immune function. The lab uses a combination of bioinformatics, biochemistry, animal modelling, CRISPR screening and single-cell omics in human and mouse systems to understand how mito-SEPs regulate cellular processes related to energy production. For more information, please visit

We are seeking a collaborative, dynamic and self-motivated Research Fellow to join the team of Dr. Lena Ho at Duke-NUS Medical School. The selected candidate will perform a variety of research activities, including but not limited to the following:

  • Conduct research to address how oxidative phosphorylation and its associated metabolites control innate and adaptive immunity against pathogen infection.
  • Write and review research papers, present research outcomes, conceptualise new ideas and develop plans for independent research which could have a considerable influence and impact on the relevant field attracting research funding.
  • Provide support for external grant/protocol development, study design and management of research activities.
  • Maintain optimal experiment progress in the laboratory or in the research work undertaken.
  • Perform other related duties incidental to the work described therein.

Job Requirements

  • PhD in a related scientific area and/or post-graduate medical degree.
  • Possesses expertise and interest in the following areas: Mitochondrial biology, Innate and adaptive immunology, Immuno-metabolism, inflammation or host-pathogen immune interactions, Bioinformatics surrounding metabolic modelling, single-cell or spatial transcriptomics and Mouse models of infection and inflammation. 
  • Knowledge of the scientific background relevant to the research area and laboratory experimental skills, where applicable.
  • Proven track record in the form of high impact publications.
  • Demonstrated capability of research independence progressively.
  • Strong writing and critical thinking skills, as well as good communication and presentation skills.
  • A team player who is able to prioritise, multi-task and work collaboratively in a diverse workforce.

We regret that only shortlisted candidates will be notified. 

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presences are required. 

In accordance with Singapore's legal requirements, unvaccinated workers will not be able to work on the NUS premises with effect from 15 January 2022. As such, job applicants will need to be fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Outram Campus
Organization: Duke-NUS Medical School
Department : Office of Research
Employee Referral Eligible: No
Job requisition ID : 12129

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