Postdoc position in prion research at the University of Calgary

Location
Calgary (City), Alberta (CA)
Salary
Up to CAN$ 55,000 per annum + benefits
Posted
09 Nov 2022
End of advertisement period
09 Dec 2022
Contract Type
Fixed Term
Hours
Full Time

Postdoc position in prion research at the University of Calgary (Zoonotic potential of chronic wasting disease).

The prion research group of Dr. Schatzl at the University of Calgary is looking for enthusiastic postdoctoral fellows and provides a competitive salary and an inspiring research environment. Funding is secured for several years from NIH and Canadian sources. Position is initially for one year and can be extended.

Prion diseases are fatal and infectious neurodegenerative disorders of man and animals. Chronic wasting disease (CWD) is an expanding prion disease of deer and elk in Northern America and Scandinavia. The postdoc project will characterize the zoonotic potential of CWD that is unclear to date. The group has provided evidence by transmission experiments to different transgenic mouse models and bank voles that Cynomolgus macaques inoculated via different routes with CWD-positive cervid tissues harbor infectious prions. The proposed studies will unravel the properties of these prions, how they will adapt to humans and which pathways are activated in brain cells and associated with clinical disease. Results from these studies will uncover the potential manifestation of CWD in humans, which is highly relevant for human health. Experimental models used will include transgenic mice, bank voles, gene-edited cells, primary cells, immunoblot, prion conversion assays, IHC, and single-cell RNASeq.

The postdoc is involved in training undergraduate and graduate students, and participates in writing of papers, reviews, research reports and grant proposals. The Schatzl lab presently consists of lab manager, postdocs, lab technician, graduate and undergraduate students, and offers a unique training environment for postdocs. The group collaborates closely with the group of Dr. S. Gilch (see Hannaoui et al., 2022) and with various other groups and has a longstanding expertise in training highly qualified personnel.

Required qualifications are a recent PhD (or equivalent) in cellular or molecular biology, infectology, biochemistry, neuroscience or related areas. At least 2 years of experience in research is required; research activities in bio-safety level 2 environments and experience with infectious disease research are considered an asset. Ability to work with hazardous chemicals, infectious agents and live animals is required.

The University of Calgary is a leading Canadian university located in the nation’s most enterprising city. Named a cultural capital of Canada and one of the best places to live in the world, Calgarians benefit from a strong economy and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour’s drive from the majestic Rocky Mountains (Banff and Jasper National Parks) and boasts the most extensive urban pathway and bikeway network in North America. If you are interested in joining an ambitious research team, please send your application containing a statement of previous research experience and details about your interest in the position, a CV, and a list of three referees via email to:

Hermann M. Schatzl, MD/PhD, Professor, Prion Biology and Immunology, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada; Email: hschaetz@ucalgary.ca

 

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