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Research Fellow, Mechanobiology Institute

Job Description

The Mechanobiology Institute (MBI), National University of Singapore is seeking to recruit a Postdoctoral Fellow (Research Fellow) to join Asst. Prof. Jennifer Young’s Soft Nano-Biomaterials group. The group aims to characterize and recapitulate nanoscale extracellular matrix (ECM) properties of healthy and diseased tissues in order to better understand cellular behavior and clinical outcomes. Most diseases result in, or stem from, alterations in ECM, yet to-date, nanoscale properties of tissues are poorly understood. This lack of knowledge of the tissue nanoenvironment poses a critical barrier to better understanding ECM-directed cellular behavior that can later be exploited for clinical applications.

The specific project in this call focuses on age-related ECM remodeling in the heart as part of the newly funded project M2CardAGE: Molecular and Mechanobiology Underpinning Cardiac Ageing. The chosen fellow will work toward imaging ex vivo tissue samples of young and aged hearts at high resolution using electron microscopy (EM) combined with immunogold labeling. These data will be compared to histological and mechanical analyses of matrix components to understand the links between observed age-related alterations and mechanobiological processes. Previous experience in EM and tissue handling techniques are a plus, but training can be organized if the candidate lacks experience. This project will ultimately result in a novel imaging workflow that can be applied across various disease models/tissue types, allowing for widespread relevance in numerous biological contexts.

Qualifications

Candidates with a PhD in engineering, biology, biomedical sciences, or similar are encouraged to apply. They should have a strong background in ECM/tissue biology, electron microscopy, and/or image analysis. Prior knowledge of EM and/or tissue preparation are not a prerequisite but can be advantageous. The candidate should possess excellent communication skills and engage in collaborative research in a highly interdisciplinary environment.

Salary and benefits are commensurable to educational qualifications and working experience of the candidates.

The MBI and NUS provide state-of-the-art facilities dedicated to EM and high-resolution imaging that will support the fellow in training, setup, and execution of the project.

TO APPLY

Applications should be sent via email to Asst. Prof. Jennifer Young at biejly@nus.edu.sg. Application documents include: 1) a brief description of research interests and experience, and 2) a full CV, with the names and contacts (email addresses) of two to three references.

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Kent Ridge Campus
Organization: Mechanobiology Institute
Department : Mechanobiology Institute
Employee Referral Eligible: No
Job requisition ID : 15481

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