Research Associate in Bioinformatics

Location
London (Greater) (GB)
Salary
£38,826 per annum, including London Weighting Allowance
Posted
15 Sep 2022
End of advertisement period
28 Sep 2022
Ref
054495
Contract Type
Fixed Term
Hours
Full Time

Job description

We are seeking a talented and highly motivated Postdoctoral Bioinformatician to develop and implement approaches to computational analysis of clinical trials datasets. The post holder will work closely with neuroscientists and computational groups within the King’s MND Care and Research Centre. The successful candidate will apply multi-omics approach in the analysis of clinical trials data to perform polygenic and poly-methylation risk score analyses and develop risk prediction models.  

The postholder will develop, maintain and run bioinformatics pipelines to analyse large genetic, epigenetic, clinical and lifestyle datasets of patients affected by motor neuron disease (MND) to investigate the genetic and epigenetic basis of MND. Such datasets include whole-genome sequencing, methylation arrays, SNP arrays and clinical information of over 10,000 individuals, the majority of whom are people with MND. Lifestyle and RNAseq data are also available for a subset.   

The post holder will be expected to collaborate closely with members of the Department of Basic and Clinical Neuroscience. 

The postholder should have experience in the development of genomic bioinformatics tools and methods. The postholder will also be expected to collaborate with the members of large international collaborations such as the EU JPND funded STRENGTH and BRAIN-MEND consortia and Project MinE. 

 

This post will be offered on an a fixed-term contract until 30/09/23 

This is a full-time  post - 100% full time equivalent

 

Key responsibilities

  • Aid in the development of new neurodegenerative disease therapies by supporting the exploratory, pre-clinical, set-up, monitoring and archiving aspects of early phase 2 clinical trials 
  • Lead analyses and write scientific publications arising from the research, serving as first author. 
  • Ensure data collection and record keeping are conducted in a good scientific manner 
  • Perform polygenic risk score analyses and develop risk prediction models 
  • Develop, maintain and run bioinformatics pipelines and workflows focusing on DNA Next Generation sequencing data to support high quality research output. 
  • Conduct genetic and epigenetic analysis of neurodegenerative diseases 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

Skills, knowledge, and experience

  1. Evidence of playing a key role in a leading-edge research project 
  2. Experience of working with colleagues as part of team and collaboration with other groups 
  3. Knowledge and use of version control systems (GitHub, Subversion, Bitbucket) 
  4. Familiarity with biomedical research, preferably molecular biology, genetics or neuroscience 
  5.  Experience in epigenetics data research 

Essential criteria  

1. PhD in a relevant subject (e.g. bioinformatics or computer science) or equivalent experience in relevant area. 

2. Up to date knowledge of next generation sequencing (DNA and/or RNA-seq) pipelines. 

3. Ability to use and develop bioinformatics tools for large scale data analysis, integration, mining and visualization. 

 

Desirable criteria

1.Programming in at least one language on a Linux platform (e.g Python, Java, Bash, Perl, R) 

2.Knowledge and use of version control systems (GitHub, Subversion, Bitbucket) 

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