NATIONAL UNIVERSITY OF SINGAPORE

Research Assistant, Antibiotics Project

1 day left

Location
Singapore
Posted
07 Sep 2022
End of advertisement period
07 Oct 2022
Ref
10042844
Contract Type
Permanent
Hours
Full Time

Job Description

In response to this threat to the future of medicine, we aim to develop novel antibiotics using the conjugated oligoelectrolyte (COE) antibiotics. COEs are defined by a linear hydrophobic conjugated backbone with polar ionic pendants at both terminals. The modular design of COEs allows for rapid tuning of molecular fragments to access a large continuum of properties. They were firstly synthesized in Prof. Bazan’s group as two-photo absorption chromophores and later found to have biological applications as antimicrobial agents.

This project aims to characterize the antibacterial activity of COEs against a panel of bacteria. Routine assays will be performed on the COEs, including minimal inhibitory concentration (MICs), minimal bactericidal concentration (MBCs), time-kill kinetics, and synergistic studies with commercial antibiotics. The cytotoxicity of COEs against mammalian cells will be routinely examined. The characterization and applications for these COE-treated biological samples will also be investigated via different fluorescence-based techniques such as confocal microscopy and flow cytometry.

Training will be provided for the assays and techniques required for this project. The project will be mentored and discussed by postdoc research fellow and principal investigator on a routinely basis.

Qualifications

  • The candidate must have a Bachelor Degree with Honours or its equivalent 
  • Independent and motivated individual with good problem-solving skills 
  • With practical experience and/or knowledge of: 
    • Microbiology, cell biology, or biochemistry
    • Characterization techniques including absorbance/fluorescence measurements, flow cytometry or fluorescent microscopy
    • Microsoft office
    • Understanding of aseptic techniques in laboratory and experience in a biosafety level 2 lab is a plus

Interested applicants may email your resume to Prof. Bazan (chmbgc@nus.edu.sg) and Kaixi (kzhang@nus.edu.sg)

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.

Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Kent Ridge Campus
Organization: Science
Department: Chemistry
Employee Referral Eligible: No
Job requisition ID: 16827

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