Skip to main content

This job has expired

Research Associate in Comprehensive Cancer Centre

Employer
KINGS COLLEGE LONDON
Location
London (Central), London (Greater) (GB)
Salary
£34,502 - £39,333 inclusive of London Weighting Allowance
Closing date
15 Oct 2022

View more

Academic Discipline
Life sciences
Job Type
Research Related, Research Assistants / Officers
Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description

 

This is a research support post within the Comprehensive Cancer Centre and the Molecular Immunology Group at the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at the Guy’s campus of King’s College London. These groups are working on a number of projects relating to antigen presentation and T cell response in cancer and inflammation with the aim to further characterise the underlying molecular mechanisms and identify potential diagnostic and therapeutic targets. 

 

The focus of this post will be to carry out a project on myeloproliferative neoplasia (MPN) funded by Blood Cancer UK (BCUK) for 3 years. The name of the project is: Identifying unconventional neoepitopes and immune phenotypes in Myeloproliferative Neoplasia to facilitate personalised combined immunotherapies.

 

The successful candidate will be expected to lead, under the supervision of Dr Mishto and Dr. Kordasti, a programme of research whose principal aims are: 

 

(i) discovery noncanonical (mutated) epitopes relevant in MPN immunotherapy. 

(ii) isolating CD8+ T cell clones specific for HLA-I-restricted neoepitopes carrying recurrent driver mutations in MPN, and cloning their TCRs to investigate the epitope generation in cancer cells; 

(iii) investigate the MPN immunome using CyTOF technology. 

 

Detailed knowledge of applied cellular and molecular biology and immunobiology, biochemistry and cloning would be highly advantageous.  

The successful candidate will have opportunities to interact with national and international collaborators with a broad expertise, which varies from computational biology to clinics, as well as Mishto lab at the Francis Crick Institute (London, UK). 

 

This post will be offered on  a fixed-term contract for 3 year 

This is a full-time post

 

Key responsibilities

•   Isolation of CD8+ T cell clones  

•   TCR sequencing and cloning in viral expressing vectors 

•   CyTOF analysis 

•   FACS, cell sorting 

•   Molecular and cellular immunology experiments 

•   Participating actively in related research projects, for example those looking at immune responses to antigenic peptides in patients 

•   Develop, lead and conduct designated research projects in collaboration with members of the group, department, division or the faculty and initiate and conduct research collaborations nationally and internationally.  To be responsible for co-ordinating and implementing research projects 

•   To make research initiatives and original contributions to the research programme wherever possible, including funding applications and to contribute freely to the team research environment in a manner conducive to the success of the research project as a whole 

 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

 

Skills, knowledge, and experience

 

•       flow cytometry 

•       ELISA, EliSpot 

•       CyTOF 

•       Western blots, proteomics  

•       long-term tissue culture 

•       basic molecular biology/biochemistry 

•       bioinformatics 

 

Essential criteria  

1.       A PhD in Cell or Molecular Biology, Biochemistry, Immunology or a related subject  

2.       Track record of peer-reviewed scientific publications 

 

Desirable criteria

1.        Excellent knowledge and understanding of cell biology, molecular immunology, antigen presentation, T and B cell biology 

2.       Experience of mammalian cell culture 

3.       Experience of working with cell culture, molecular and cell biology projects, antigen presentation, T and B cells 

4.       Experience of working with flow cytometry 

5.       Extensive experience in modern cellular, molecular biology, biochemistry and imaging techniques 

6.       Experience of T Cell clone generation and maintenance 

7.       Effective time management and organisational skills 

8.       Ability to communicate effectively with researchers 

9.       Ability to manage a busy research project

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
United Kingdom

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert