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Research Assistant in Preclinical Development of Ultrasound-Mediated Paediatric Brain Tumour

Employer
KINGS COLLEGE LONDON
Location
London (Greater)
Salary
£34,502 – £39,333 per annum, including London Weighting Allowance
Closing date
5 Sep 2022

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Academic Discipline
Clinical, Pre-clinical & Health
Job Type
Research Related
Contract Type
Fixed Term
Hours
Full Time

Job Details

Job description

We are looking for an enthusiastic Research Assistant to work on a pre-clinical project related to ultrasound-mediated paediatric brain tumour treatment using drug-loaded thermosensitive liposomes.   

 

The successful candidate will have a good understanding of cell culture and animal husbandry. The post involves cell culture of fluorescent diffuse midline glioma (DMG) cell lines, brain tumour inoculation, monitoring of tumour growth using magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF)/luminescence imaging, and animal husbandry (mice). The research assistant will also be responsible for post-mortem tissue processing, sectioning, histology, and microscopy imaging. Finally, they will work on the development of the MHRA application for clinical translation of the study’s findings. 

 

The post-holder will join an exciting pre-clinical project in the heart of London, funded by the Little Princess Trust. The project is highly translational and its results will be used for the design of future clinical trials. The project will be based in the Department of Surgical & Interventional Engineering, within the School of Biomedical Engineering and Imaging Sciences, at King’s College London. Ultrasound and MRI experiments will be conducted at St Thomas Hospital. Chemical synthesis and characterisation of liposomes will be conducted in the Institute of Pharmaceutical Sciences at King’s College London, under the supervision of Dr. Maya Thanou.  

 

This post will be offered on a fixed-term contract for 3 years (latest end date 30 September 2025). 

This is a full-time post - 100% full time equivalent.

 

Key responsibilities

•        Perform DMG cancer cell culture  

•        Perform tasks related to animal husbandry 

•        Perform brain tumour inoculation and monitor tumour growth with imaging techniques 

•        Perform tissue processing, sectioning, histology, and imaging  

•        Analyse brain tissue to measure drug delivery doses 

•        Develop regulatory binder for clinical translation 

•        Collaborate with existing faculty and project partners on areas of research interest. 

•        Assist PDRAs, PhD and MSc/BSc students in relevant projects 

 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

Skills, knowledge, and experience 

Essential criteria  

1.      BSc/ MSc degree in Biology or a related STEM field 

2.      Excellent verbal and written communication skills 

3.      Wet lab skills 

4.      Experience with cell culture 

5.      Ability to work on own initiative and in a team 

 

Desirable criteria

6.      Experience with in vivo experiments (Home Office Modules 1-4) 

7.      Experience in histology 

8.      Experience in microscopy  

 

Further information

Please contact the primary supervisor ( Dr. Antonios Pouliopoulos) for informal discussions before applying to this post.

Company

King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit: www.kingshealthpartners.org.

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at www.kcl.ac.uk/kingsanswers.

Company info
Mini-site
KINGS COLLEGE LONDON
Telephone
+(44)02078365454
Location
STRAND
LONDON
WC2R 2LS
GB

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