Senior Research Scientist, Cancer Science Institute 1
Are you a biomedical researcher motivated to pursue an outstanding career in cancer research with a focus on structural biology?
Cancer will affect more than 1 in 3 Singaporeans. At the Cancer Science Institute (CSI), our mission is to be at the global forefront of research to overcome this scourge. Our innovative international faculty, cutting-edge facilities, supportive working environment and competitive package together enable each of our staff to realize their maximum potential.
We now seek a Research Scientist/ Senior Research Scientist to join the team of Prof. Ashok Venkitaraman. This is an exciting opportunity to work closely with a world-leading cancer researcher to undertake pioneering research on the role of genome instability in human carcinogenesis (eg., see Venkitaraman Science (2014) PMID:24675954 and Venkitaraman DNA Repair (2019) PMID:31337537).
This position will be jointly under Dr. Tan Yong Zi, who is an expert on single-particle cryogenic electron microscopy (cryo-EM) (see https://www.tyzlab.com/). His lab is a core member of the Centre for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. The aim of this joint position is to use cryo-EM to help solve the structures of many exciting cancer complexes to help with potential drug development.
Duties And Responsibilities
The position exists to provide
- Optimisation and performance of structural biological related experiments and projects, particularly in the field of cryo-electron microscopy
- Sample Vitrification:
- Proteins will be produced separately, hence experience in protein production is not required, although favoured
- Candidate will be responsible for optimisation of the vitrification of grids
- Data Collection:
- Candidate will oversee collecting screening and high resolution cryo-EM data from the T12 and Krios
- Data analysis:
- Candidate will oversee processing the data and producing cryo-EM maps from high resolution Krios data collections
- Candidate will help setup the processing pipeline for CSI
- Oversee training personnel from both CSI and Tan lab on cryo-EM
- PhD in cryo-EM or structural biology related field
- Firm understanding of the principles of cryo-EM
- Experience in single-particle cryo-EM sample vitrification, data collection and data processing
- Good publication record
- Excellent written and spoken English
- Friendly and personable
At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presence is required.
Taking into consideration the health and well-being of our staff and students and to better protect everyone in the campus, applicants are strongly encouraged to have themselves fully COVID-19 vaccinated to secure successful employment with NUS.