Postdoctoral Research Associate in Cancer Cell Biology

Location
London (Greater)
Salary
£38,826 - £43,239 per annum, including London Weighting Allowance
Posted
11 Jul 2022
End of advertisement period
22 Aug 2022
Ref
050207
Academic Discipline
Clinical, Pre-clinical & Health
Job Type
Research Related
Contract Type
Fixed Term
Hours
Part Time

Job description

This is an exciting opportunity for 2 postdoctoral research associates to join our dynamic, interdisciplinary team to study novel mechano-sensing mechanisms that promote tumorigenesis. The programme aims to dissect how biomechanical changes to the tumour microenvironment influence spatial changes to key pathways regulating cancer cell survival and invasion and how these influence tumour-immune cell interactions. The postholders will use a range of state-of-the-art microscopy techniques, molecular biology, and biochemical approaches in advanced 3D culture systems to understand these mechanisms and identify potential therapeutic targets for treatment of cancer. The research will be primarily undertaken at King’s College London within the Randall Centre, a world-renowned hub for biophysics excellence, with additional opportunities to work closely with KCL team members in the Comprehensive Cancer Centre and Biomedical Engineering, as well as with clinical colleagues at UCL. Access to excellent training and world class facilities will be provided, with opportunities to engage with Industry and clinical teams to drive translation of findings to a clinical setting.  

 

This post will be offered on an a fixed-term contract until 30th November 2027. 

This is a full-time post - 100% full time equivalent

 

Key responsibilities

•        Analyzing roles for biomechanics and immune cell interactions in controlling cancer cell behaviour in cell lines and in patient-derived organoids  

•        Developing new approaches to study spatial changes to cancer cell signalling events in live cells and organoids 

•        Defining novel molecular targets driving cancer drug resistance for potential personalised medicine approaches 

•        Working both independently and as part of a diverse inter-disciplinary team 

•        Presenting work at national and international meetings 

•        Writing papers and supervising other team members 

 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

Skills, knowledge, and experience 

Essential criteria  

1.      BSc and PhD in relevant subject area  

2.      Background in cancer cell biology, biomechanics, and/or immuno-oncology 

3.      Prior experience in human cell culture, biochemistry, molecular biology and 3D cell culture 

4.      Prior experience in advanced fluorescence microscopy and bioimage analysis 

5.      Experience working in multidisciplinary, collaborative team environments  

6.      Strong communication skills 

7.      Ability to write scientific documents and papers 

8.      Strong presentation skills 

 

Desirable criteria

1.      Prior experience working with patient-derived organoids 

2.      Prior experience working with human tissues 

3.      Background knowledge in cytoskeletal signalling and DNA damage response pathways 

 

Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6. 

Further information

Interviews are expected to be held in the week commencing 12th September 2022

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