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Gene Therapy Post Doctoral Research Associate

London (Greater) (GB)
£38,826 - £45,649 per annum, including London Weighting Allowance
Closing date
6 Jul 2023

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Job Details

Job description

We are seeking to appoint two organised and enthusiastic Post-Doctoral Research Associates. 


The successful candidates will be part of a team testing viral vector gene therapy reagents aimed at treating amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD) on a commercially funded project.  


The aim of the project is to optimise the dose and delivery of gene supplement and knock-down vectors in cellular and animal models of disease as proof of concept and efficacy for potential clinical application.  


Working with Professor Shaw and Dr Youn Bok Lee they will join a team of technicians and post-doctoral scientists analysing cells and tissues transduced with plasmid and vector constructs and quantify the effects on target gene expression.  


For in vivo work the candidate will sacrifice animals and harvest and prepare tissues for histological sectioning, staining, imaging and quantitative analyses. All experiments will be undertaken at a very high standard and all data treated with complete confidentiality 


You will join a research group based within the UK Dementia Research Institute (DRI) centre that is embedded within the Department of Basic and Clinical Neuroscience at King’s College London ( within the Maurice Wohl Clinical Neuroscience Institute on the Denmark Hill campus.  


The DRI is a national consortium focused on cutting-edge dementia research funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK (   


This post will be offered on an a fixed-term contract till March 31 2023 

This is a full-time  post - 100% full time equivalent


Key responsibilities

•         Perform laboratory work to optimise the efficiency of our preclinical studies.  

•         Deliver high-quality data from our preclinical studies including:  

•         Undertake rodent colony care, breeding and genotyping  

•         Optimise perfusion, harvesting, fixation and sectioning of animal tissues. 

•         Image tissues using slide scanning and confocal microscopes 

•         Undertake image analysis using advanced analytical software tools 

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.  

Skills, knowledge, and experience

Strong experience of  

•         In vivo experimental methods 

•         Rodent colony maintenance and genotyping  

•         Tissue collection and processing for immunohistochemistry and biochemistry 

•         Advanced microscopy using confocal imaging  

•         Quantitative image analytical software and statistical analyses 

•         AAV gene transduction and expression 


Essential criteria  

1.       PhD in Neuroscience or equivalent biological field 

2.       An ability to work independently and within a team 

3.       Attention to detail and high standards of accuracy in all work 

4.       Conscientious and organised 

5.       Ability to time manage appropriately  

6.       Willing to work occasionally during weekends and bank holidays 


Desirable criteria

1.       Experience of AAV gene therapy


King's College London is one of the top 20 universities in the world and among the oldest in England. King's has more than 27,600 students (of whom nearly 10,500 are graduate students) from some 150 countries worldwide, and some 6,800 staff.

King's has an outstanding reputation for world-class teaching and cutting-edge research. In the 2014 Research Excellence Framework (REF) King’s was ranked 6th nationally in the ‘power’ ranking, which takes into account both the quality and quantity of research activity, and 7th for quality according to Times Higher Education rankings. Eighty-four per cent of research at King’s was deemed ‘world-leading’ or ‘internationally excellent’ (3* and 4*). The university is in the top seven UK universities for research earnings and has an overall annual income of more than £684 million.

King's has a particularly distinguished reputation in the humanities, law, the sciences (including a wide range of health areas such as psychiatry, medicine, nursing and dentistry) and social sciences including international affairs. It has played a major role in many of the advances that have shaped modern life, such as the discovery of the structure of DNA and research that led to the development of radio, television, mobile phones and radar.

King's College London and Guy's and St Thomas', King's College Hospital and South London and Maudsley NHS Foundation Trusts are part of King's Health Partners. King's Health Partners Academic Health Sciences Centre (AHSC) is a pioneering global collaboration between one of the world's leading research-led universities and three of London's most successful NHS Foundation Trusts, including leading teaching hospitals and comprehensive mental health services. For more information, visit:

King’s £600 million campaign, World questions|KING’s answers, has delivered huge global impact in areas where King’s has particular expertise. Philanthropic support has funded new research to save young lives at Evelina London Children’s Hospital; established the King’s Dickson Poon School of Law as a worldwide leader in transnational law; built a new Cancer Centre at Guy’s Hospital; allowed unique collaboration between leading neuroscientists to fast-track new treatments for Alzheimer’s, Parkinson’s, motor neurone disease, depression and schizophrenia at the new Maurice Wohl Clinical Neuroscience Institute; created the Cicely Saunders Institute: the first academic institution in the world dedicated to palliative care, and supported the King’s Sierra Leone Partnership in the Ebola crisis. Donations provide over 300 of the most promising students with scholarships and bursaries each year. More information about the campaign is available at

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United Kingdom

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