Job Description

The successful candidate will work with Assistant Professor Brandon I Morinaka on the production and characterization of a new class of cyclic peptides using posttranslational modifying enzymes under a project on Next-generation peptides for infectious diseases.

The RF will be responsible for leading a project that involves the formation of novel cyclic peptides using enzymes. The cyclic peptides will be produced by either heterologous expression in Escherichia coli - or - by using purified enzymes. The subsequent products will be purified by chromatographic techniques and the structures determined by spectroscopic methods (LC-MS, NMR, and degradation/synthesis). Finally, the peptide products will be tested in bioassays relevant to infectious diseases for the identification of new bioactive peptides. The candidate should have a strong background in natural products chemistry or biosynthesis, excellent communication skills, and the ability to work in a team.

Other responsibilities include training of students/staff and maintenance/repair of equipment.

Qualifications

• Qualifications / Discipline: The candidate must possess a PhD in the Sciences with a focus on biochemistry/molecular biology, chemical biology, natural products chemistry/biosynthesis, or a field relevant to the researc
• Skills: Analytical chemistry (HPLC, Mass spectrometry, and Nuclear magnetic resonance). Molecular biology and biochemistry (cloning, PCR, protein expression, SDS-PAGE, CRISPR/CAS9) 
• Experience:  Bioinformatic analysis of natural product gene clusters. Isolation and structure elucidation of natural products. Cloning and expression of natural product enzymes and pathways.

Covid-19 Message

At NUS, the health and safety of our staff and students are one of our utmost priorities, and COVID-vaccination supports our commitment to ensure the safety of our community and to make NUS as safe and welcoming as possible. Many of our roles require a significant amount of physical interactions with students/staff/public members. Even for job roles that may be performed remotely, there will be instances where on-campus presences are required.

In accordance with Singapore's legal requirements, unvaccinated workers will not be able to work on the NUS premises with effect from 15 January 2022. As such, job applicants will need to be fully COVID-19 vaccinated to secure successful employment with NUS.

More Information

Location: Kent Ridge Campus
Organization: Science
Department : Pharmacy
Job requisition ID : 13749