UK Dementia Research Institute Group Leader

London (Greater) (GB)
£43,434 - £64,298 per annum
08 Jun 2022
End of advertisement period
01 Sep 2022
Contract Type
Full Time

Job description

Dementia is the greatest health challenge of our century.

To date there is no way to prevent it or even slow its progression, and there is an urgent need to fill the knowledge gap in our basic understanding of the diseases that cause it.

The   UK Dementia Research Institute (UK DRI) is the biggest UK initiative driving forward research to fill this gap.


We are a globally leading multidisciplinary research institute of 700 staff investigating the spectrum of neurodegenerative disorders causing dementia, with laboratory-based research groups located at University College London, the University of Cambridge, Cardiff University, Edinburgh University, Imperial College London and King’s College London.


Researchers at the   UK DRI at King’s use innovative approaches to explore the biological mechanisms involved in neurodegenerative diseases. Their goal is to defeat dementia by uncovering vital new knowledge that will lead to the design of smarter diagnostics and effective treatments. The team aim to understand the fundamental biological processes involved in dementia at a molecular level – and to use that knowledge to design new ways to diagnose and treat disease more precisely.

As part of the continued growth of the UK DRI at King’s College London the   Department of Basic and Clinical Neuroscience is seeking a clinical or nonclinical academic to initiate a novel programme of research into neurodegeneration. We seek creative

and innovative proposals for a new research programme in areas including but not limited to:

- Compartmentalised and spatiotemporal RNA regulation of neuronal RNA transport and/or local translation, and its roles in the local regulation of neuronal synaptic plasticity.

- Effects of disease-causing mutations on ribonucleoprotein condensates, with methods such as advanced imaging and biophysics.

- Computational integrative studies of high-throughput data and dynamic modelling of regulatory RNA circuits.

- Therapeutics and neurotechnology, such as new approaches for gene therapy, viral and non-viral vectors and their targeted delivery to the brain.


Whilst we are particularly interested in the above areas, we welcome applications from clinical and nonclinical academics with any research interest that will contribute to the aim of our centre to characterise the mechanisms of protein-RNA complexes and their impairments in ALS and develop new therapeutics with AAV- and antisense RNA-based delivery.


Please note the salary range mentioned is based on both Clinical and non-clinical pay structure. The salary that will be offered to the suitable candidate, will be based on either Clinical or Non Clinical.

For informal queries, please contact UK DRI director Professor Jernej Ule (


This post will be offered on an permanent contract.

This is a full-time post - 100% full time equivalent



Key responsibilities

  • Successfully attract research funding
  • Build and provide research leadership of a group of research scientists, comprising postdoctoral fellows, PhD students and technical support staff
  • Plan the scientific direction of the research programme aimed at key questions within the overall scientific remit of the centre and institute; being accountable for presenting the programme for peer review in accordance with the funders’ procedures.
  • Contribute to the overall scientific mission of the UK DRI and the HEI.
  • Direct the activities of the research group by supervising some projects personally and overseeing projects delegated to group members. You will be expected to provide the intellectual energy and independent thinking necessary to lead and deliver a programme of cutting-edge research and to shape the overall aims and success of the group.
  • Disseminate the research outputs from the group by publication of results, presentations at scientific meetings and responding to media enquiries.
  • Work as a scientific leader within the UK DRI institute and promoting this concept within the group and more widely
  • Determine and manage the resource requirements to sustain the programme, including the staffing structure required for taking forward the programme of research to success.
  • With operational support, maintain oversight and responsibility for the recruitment, management, training and career development of group members, including line management and performance management, in accordance with the UK DRI and King’s College London policies and procedures.
  • Generate and manage collaborations both within the centre, the UK DRI, King’s College London and with external establishments.
  • Identify and act on opportunities for the creation of intellectual property and cooperating in patent protection and in exploitation according to UK DRI and King’s College London policy.
  • Maintain a broad, balanced and informed perspective of current scientific issues especially those pertaining directly to the field of research.
  • Contribute to scientific progress in the field as a whole by, for example, membership of expert committees, editing specialist journals and refereeing funding applications.
  • Contribute to public communications initiatives to facilitate greater public engagement with science and specifically, contributing to engagement with patients and their carers
  • Ensure all research within the programme is conducted in accordance with good practice and in compliance with UK DRI and King’s College London policies and legal requirements.
  • Commit to the IoPPN Code of conduct

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.


•        Nonclinical and clinical appointment require postgraduate degree at PhD level in a related subject area or relevant experience

•        Clinical appointment requires full GMC registration

Skills, knowledge, and experience

•        Proven ability to demonstrate creativity, innovation and team working within work

•        Proven commitment to diversity and inclusion


Essential criteria

  1. Well-established expertise, reputation, and proven portfolio of research.

  2. A record of publications that initiated new research directions and impacted the research of other teams.

  3. Established record of attracting external research funds

  4. Expert knowledge in a relevant research area and able to direct, plan and carry out independent programme of research

  5. Established reputation within academic field or within a clinical context

  6. Proven ability to collaborate with other researchers and promote the sharing of knowledge and expertise

  7. Ability to value, relate to and support colleagues, junior staff, visitors, and students and to contribute to a healthy and cooperative team ethos

  8. Proven interest in and commitment to the mission and research of the UK DRI and the UK DRI at King’s College London

  9. Proven ability to attract PGRs and experience of successfully working with, supervise and develop postgraduate students

  10. Proven ability in effective and persuasive communication

  11. Nonclinical and clinical appointment require postgraduate degree at PhD level in a related subject area or relevant experience

  12. Clinical appointment requires full GMC registration

Desirable criteria

  1. Proven record of contributing and leading successful research bids.
  2. Experience of working or collaborating with industry on topics related to the proposed research

Further information

Please be aware that King’s College London reserves the right to close this vacancy early should sufficient applications be received.


Please note the salary range mentioned is based on both Clinical and non-clinical pay structure. The salary that will be offered to the suitable candidate, will be based on either Clinical or Non Clinical.

For informal queries, please contact UK DRI director Professor Jernej Ule (


King’s College London is committed to supporting and promoting equality and diversity. Our centre aims to increase the number of women in senior scientific positions. Our inclusive environment welcomes applications from talented people from diverse backgrounds.

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