MASARYK UNIVERSITY

Post-doc, Faculty of Medicine

Location
Brno, Czech Republic
Posted
21 Apr 2022
End of advertisement period
12 Jun 2022
Ref
68780
Contract Type
Permanent
Hours
Full Time

Department: Pavel Krejčí Research Group – Faculty of Medicine
Deadline: 12 Jun 2022
Start date: According to the agreement
Job type: full-time
Job field: Science and research

Faculty of Medicine, Masaryk University, Brno, Czech Republic looks for a  Post-doc for the project aiming to resolve A role of phosphodiesterases in bone and cartilage.

Annotation of the project:

Phosphodiesterases (PDEs) are enzymes that regulate intracellular level of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), the second messengers used by many signaling pathways. In bone, cAMP and cGMP are used to regulate proliferation of chondrocytes, bone remodeling and endochondral ossification. Understanding the role of PDEs in bone and cartilage could help to prevent bone/cartilage degeneration or improve bone growth.

Enthusiastic, motivated young scientists with a background in cell biology, molecular biology or a similar field are welcome to join this translation medicine research project.

We offer an interesting clearly defined and financed project

  • stimulating dynamic international environment of well-established research group
  • techniques involving protein analysis by western blotting and confocal microscopy, gene expression profiling of mouse and human tissue, experimental therapy on mouse models of human diseases
  • using CRISPR/Cas9 system for gene targeting in cells
  • an opportunity of career development
  • competitive salary

For further information please contact Mgr. Bohumil Fafílek, Ph.D.

Contact: tel: +420 549 49 6802, e-mail: fafilek@med.muni.cz

Supervisor´s 5 best publications:  Gastroenterology 2013, 144(2):381-391

Science Signaling 2018, eaap8608

Cellular Signaling 2011, 23(5):837-848

Elife 2017; 6. pii: e21536

Osteoarthritis and Cartilage 2017, 25(9):1522-1530

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