This is an exciting opportunity to join a team of multi-disciplinary scientists and help understand how lung epithelial cells influence responses to inflammatory insults. The project will study a key receptor we have identified as a mediator of inflammatory lung diseases and lung cancer progression and dissect the signalling mechanisms by which this receptor controls epithelial homeostasis. The study will use a range of state-of-the-art microscopy techniques, molecular biology, and biochemical approaches in vitro and in vivo to understand these mechanisms and identify potential therapeutic targets for treatment of lung inflammatory disease and cancer. Access to excellent training and world class facilities will be provided, with opportunities to engage with Industry and clinical teams to drive translation of findings to a clinical setting.
This post will be offered on a fixed-term contract until 31st March 2025.
This is a full-time post - 100% full time equivalent
- Analyzing roles for key adhesion receptors in controlling epithelial cell homeostasis, response to inflammatory cues and disease progression both in vitro and in vivo
- Developing new approaches to study lung epithelial and cancer cell signalling events in live cells and tissues
- Defining novel molecular targets driving inflammatory lung disease and cancer
- Working both independently and as part of an inter-disciplinary team
- Presenting work at national and international meetings
- Writing papers and supervising other team members
The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.
Skills, knowledge, and experience
1. BSc and PhD in relevant subject area
2. Background in epithelial/cancer cell biology, receptor signaling and/or tissue biology
3. Prior experience in human cell culture, biochemistry, molecular biology and tissue handling
4. Prior experience in advanced fluorescence microscopy and image analysis
5. Experience working in multidisciplinary, collaborative team environments
6. Strong communication skills
7. Ability to write scientific documents and papers
8. Strong presentation skills
1. Background in respiratory biology
2. Home office personal license or prior experience in animal work
* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.
Selection process will include a panel interview.
This post is not subject to Occupational Health clearance.