NATIONAL UNIVERSITY OF SINGAPORE

Research Fellow, Mechanobiology Institute

Location
Singapore
Posted
10 Jan 2022
End of advertisement period
09 Feb 2022
Ref
6410844
Contract Type
Permanent
Hours
Full Time

Job Description

We are seeking to recruit a Research Fellow (Postdoctoral Fellow) in nanobiotechnology at Mechanobiology Institute, National University of Singapore.  The research project aims to elucidate mechanisms of cellular adaptations to aging process and are jointly supervised by Mechanobiology Institute, National University of Singapore (MBI, NUS;  PI: Assoc. Prof. Pakorn Kanchanawong) and Nanyang Technology University (NTU, PI: Asst Prof. Zhao Wenting).  The research project is devoted to the study of nanoscale membrane reorganization in aging using nanofabrication-enabled cellular manipulation in conjunction with high-resolution live cell imaging, per references below.

References

  1. "Tutorial: using nanoneedles for intracellular delivery."  Chiappini, C., Chen  Y., Aslanoglou  S., Mariano A., Mollo V., Mu H., De Rosa E., He G., Tasciotti E., Xie X., Santoro F.,  Zhao, W.T., Voelcker  N. H. and Elnathan R., Nature Protocols, 2021, 12, 4539-4563..
  2. "Comparative Study of Curvature Sensing Mediated by F-BAR and an Intrinsically Disordered Region of FBP17." Su, M., Zhuang Y., Miao X., Zeng Y., Gao W., Zhao, W.T. and Wu M. iScience, 2020, 23(11): 101712.
  3. "Membrane curvature underlies actin reorganization in response to nanoscale surface topography", Lou, H.Y.; Zhao, W. T.; Li, X.; Duan, L.; Powers, A.; Akamatsu, M.; Santoro, F.; McGuire, A.F.; Cui, Y.; Drubin, D.G.; Cui, B.X., Proceedings of the National Academy of Sciences, U. S. A., 2019, 116 (46), 23143-23151.
  4. "A nanostructure platform for live cell manipulation of membrane curvature", Li, X., Matino L., Zhang, W., Klausen, L., McGuire, A., Lubrano, C., Zhao, W.T., Santoro, F., Cui, B.,  Nature Protocols, 2019, 14, 1772–1802.
  5. "The role of membrane curvature in nanoscale topography-induced intracellular signalling". Lou, H.Y.; Zhao, W. T.; Zeng, Y., Cui, B. X., Accounts of Chemical Research, 2018, 51 (5), 1046–1053.
  6. "Nanoscale manipulation of membrane curvature for probing endocytosis in live cells". Zhao, W. T.; Hanson, L.; Lou, H.Y.; Akamatsu, M.; Chowdary, P.; Santoro, F.; Marks, J.; Grassart, A.; Drubin, D. G., Cui, Y.; Cui, B. X., Nature Nanotechnology, 2017, 12, 750-756.
  7. "Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells". Hanson, L.; Zhao, W. T.; Lou, H.Y.; Lin, Z. L.; Lee, S.W.; Chowdary, P.; Cui, Y.; Cui, B. X., Nature Nanotechnology, 2015, 10, (6), 554-562.

Responsibilities

  • Design, develop, perform, and implement scientific project on nanoscale membrane dynamics in cells.
  • Collaborate with other team members, train and supervise junior laboratory members
  • Write scientific manuscript and assist with grant proposal preparation.

Qualifications

  • A Ph.D in materials science, chemistry, biophysics, biomedical engineering or related disciplines. Background in material surface engineering is highly preferred.
  • Recent Ph.D graduates with less than 2 year experience are preferred.
  • Strong track record in research accomplishment, such as having high quality first-authored publications.
  • Extensive experiences in nanomaterials synthesis, surface patterning, topography engineering, nano-/micro-fabrication and related techniques.
  • Experiences in mammalian cell culture, immunofluorescence microscopy, cell transfection, and background knowledge in cell adhesion and gene transcription regulation.
  • Experiences in advanced microscopy, high-resolution cell imaging, and computer-based image analysis is desirable.

Please attach your full CV, with the names and contacts (including email addresses) of three references in addition to the Ph.D. supervisor.

We regret that only shortlisted candidates will be notified.

More Information

Location: Kent Ridge Campus
Organization: Mechanobiology Institute
Department : Research
Job requisition ID : 10293

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